ArticleBMC infectious diseases2018
Acute biliary events during anti-tuberculosis treatment: hospital case series and a nationwide cohort study.
Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Hepatobiliary tuberculosis in the developing world.World journal of gastrointestinal surgery · 2023Article
- Hemophagocytic Lymphohistiocytosis Activation Syndrome with Multi-Organ Co-Infections: A Therapeutic Dilemma.Kansas journal of medicine · 2023Article
- Outcome of stage IV cancer patients receiving in-hospital cardiopulmonary resuscitation: a population-based cohort study.Scientific reports · 2019Article
- Tuberculoma with phlegmon-like symptoms mimicking soft tissue sarcoma in the wrist: A case report.Molecular and clinical oncology · 2018Article
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7 authors.
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Abstract
backgroundTuberculosis (TB) remains one of the major infectious diseases worldwide. Adverse reactions are common during TB treatment. Few reports, however, are available on treatment-related acute biliary events (ABEs), such as cholelithiasis, biliary obstruction, acute cholecystitis, and cholangitis.
methodsWe first report four pulmonary TB patients who developed ABEs during anti-TB treatment. Abdominal sonography revealed multiple gall stones with dilated intrahepatic ducts in three patients and cholecystitis in one patient. To investigate the incidence of and risk factors for ABEs during anti-TB treatment, we subsequently conducted a nationwide cohort study using the National Health Insurance Research Database of Taiwan.
resultsA total of 159,566 pulmonary TB patients were identified from the database between 1996 and 2010, and among them, 195 (0.12%) developed ABEs within 180 days after beginning anti-TB treatment. Logistic regression analysis revealed that the risk factors associated with ABEs are older age (relative risk [RR]: 1.32 [1.21-1.44] per 10-year increment) and diabetes mellitus (RR: 1.59 [1.19-2.13]).
conclusionsAlthough infrequently encountered, ABEs should be considered among patients with TB who experience abdominal discomfort with hyperbilirubinemia, especially patients who have older age or diabetes.
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