ArticleBMC anesthesiology2018
Hypertension, mitral valve disease, atrial fibrillation and low education level predict delirium and worst outcome after cardiac surgery in older adults.
Article in BMC anesthesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Risk factors of delirium after cardiac surgery: a systematic review and meta-analysis.Journal of cardiothoracic surgery · 2024Pooled it
- Predisposing and Precipitating Factors Associated With Delirium: A Systematic Review.JAMA network open · 2023Pooled it
- Incidence and Risk Factors for Postoperative Delirium in Patients Undergoing Spine Surgery: A Systematic Review and Meta-Analysis.BioMed research international · 2019Pooled it
- Overtime work of anesthesiologists is associated with increased delirium in older patients admitted to intensive care unit after noncardiac surgery: a secondary analysis.BMC anesthesiology · 2024Trial
- Delirium in Patients With Traumatic Brain Injury and Long-Term Cognitive Decline: A Global Federated Real World Data Analysis.European journal of clinical investigation · 2026Article
- The association between atherogenic index of plasma and postoperative delirium in cardiac surgery patients: an analysis of the MIMIC-IV database.Perioperative medicine (London, England) · 2026Article
- Perioperative neurocognitive disorders in older patients: a narrative review of current knowledge in 2026.Perioperative medicine (London, England) · 2026Review
- Prediction of postoperative delirium after cardiac surgery by the interplay between preoperative plasma p-tau181 and IL-6 and heart-brain axis related factors: results from the prospective observational study FINDERI.Molecular psychiatry · 2026Observational
- Prediction model for postoperative delirium risk in elderly hypertensive patients: machine learning-based development and validation.Frontiers in psychiatry · 2026Article
- The Role of C-Reactive Protein as a Biomarker for Postoperative Delirium Following Cardiac and Neurosurgical Surgery: A Retrospective Analysis.Journal of clinical medicine · 2025Article
- Delirium risk factors in patients ≥ 60 years of age with recent myocardial infarction.Journal of geriatric cardiology : JGC · 2025Article
- A Prospective Nested Case-Control Study of Risk Factors for Postoperative Delirium in Elderly Patients with Colorectal Cancer.Clinical interventions in aging · 2025Article
- Development and validation of a postoperative delirium risk prediction model for non-cardiac surgery in elderly patients.Frontiers in psychiatry · 2025Article
- Association of Hypertension with Different Cognitive Disorders.Journal of clinical medicine · 2024Review
- Strategies to prevent postoperative delirium: a comprehensive evaluation of anesthesia selection and drug intervention.Frontiers in psychiatry · 2024Review
- Lipopolysaccharide-Induced Delirium-like Behaviour in a Rat Model of Chronic Cerebral Hypoperfusion Is Associated with Increased Indoleamine 2,3-Dioxygenase Expression and Endotoxin Tolerance.International journal of molecular sciences · 2023Article
- [Postoperative Delirium in Patients on Cardiopulmonary Bypass for Cardiovascular Surgeries: Incidence and Influencing Factors].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Article
- Preoperative cerebrospinal fluid biomarkers may be associated with postoperative delirium in patients undergoing knee/hip arthroplasty: the PNDABLE study.BMC geriatrics · 2023Article
- To evaluate serum cortisol levels in patients with alcohol withdrawal delirium v/s patients with delirium due to any other disorder.Journal of family medicine and primary care · 2023Article
- Prevalence and risk factors of delirium in older patients admitted to a tertiary care centre in South India: A prospective, observational study.Indian journal of anaesthesia · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDelirium is a common complication after cardiac surgery in older adult patients. However, risk factors and the influence of delirium on patient outcomes are not well established. We aimed to determine the incidence, predisposing and triggering factors of delirium following cardiac surgery.
methodsOne hundred seventy-three consecutive patients aged ≥60 years were studied. Patients' characteristics and two cognitive function assessment tests were recorded preoperatively. Perioperative variables were blood transfusion, orotracheal intubation time (OIT), renal dysfunction, and hypoxemia. Delirium was assessed using the Confusion Assessment Method for the Intensive Care Unit. The composite outcome consisted of death, infection, and perioperative myocardial infarction until hospital discharge or 30 days after surgery, and for up to 18 months.
resultsOne hundred six patients (61.27%) were men and the age was 69.5 ± 5.8 years. EuroSCORE II index was 4.06 ± 3.86. Hypertension was present in 75.14%, diabetes in 39.88%, and 30.06% were illiterate. Delirium occurred in 59 patients (34.1%). Education level (OR 0.81, 0.71-0.92), hypertension (OR 2.73, 1.16-6.40), and mitral valve disease (OR 2.93, 1.32-6.50) were independent predisposing factors for delirium, and atrial fibrillation after surgery (OR 2.49, 1.20-5.20) represented the potential triggering factor. Delirium (OR 2.35, 1.20-4.58) and OIT ≥ 900 min (OR 2.50; 1.30-4.80) were independently associated with the composite outcome.
conclusionsIn older adult patients submitted to cardiac surgery, delirium is a frequent complication that is associated with worst outcome. Independent risk factors for delirium included education level, hypertension, mitral valve disease, and atrial fibrillation after cardiac surgery.
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