ArticleCell transplantation2017
Circumferential Esophageal Replacement by a Tissue-engineered Substitute Using Mesenchymal Stem Cells: An Experimental Study in Mini Pigs.
Article in Cell transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Esophagus engineering tackles function.Nature biotechnology · 2026Article
- Functional integration of an autologous engineered esophagus in a large-animal model.Nature biotechnology · 2026Article
- Integrated biofabrication of artificial esophageal scaffolds using electrospinning, embedded DLP, and extrusion techniques.Materials today. Bio · 2025Article
- Global trends and research hotspots in esophageal strictures: A bibliometric study.World journal of gastrointestinal surgery · 2025Article
- Clinical translation of tissue-engineered oesophageal grafts: are patients ready for us?Pediatric surgery international · 2024Article
- Development and qualification of clinical grade decellularized and cryopreserved human esophagi.Scientific reports · 2023Article
- Endoscopically injectable and self-crosslinkable hydrogel-mediated stem cell transplantation for alleviating esophageal stricture after endoscopic submucosal dissection.Bioengineering & translational medicine · 2023Article
- Esophageal wound healing by aligned smooth muscle cell-laden nanofibrous patch.Materials today. Bio · 2023Article
- Current status and clinical applications of tissue engineering of the gastrointestinal tract: a systematized narrative review.Frontiers in gastroenterology (Lausanne, Switzerland) · 2023Review
- Tissue Engineering for Gastrointestinal and Genitourinary Tracts.International journal of molecular sciences · 2022Review
- Lessons learned from pre-clinical testing of xenogeneic decellularized esophagi in a rabbit model.iScience · 2022Article
- Serial evaluation of segmental esophageal reconstruction using a polyurethane scaffold in a pig model.Journal of thoracic disease · 2022Article
- Advances in The Application of Regenerative Medicine in Prevention of Post-endoscopic Submucosal Dissection for Esophageal Stenosis.Journal of translational internal medicine · 2022Article
- Engineered Full Thickness Electrospun Scaffold for Esophageal Tissue Regeneration: From In Vitro to In Vivo Approach.Pharmaceutics · 2022Article
- Esophageal regeneration following surgical implantation of a tissue engineered esophageal implant in a pediatric model.NPJ Regenerative medicine · 2022Article
- Decellularized esophageal tubular scaffold microperforated by quantum molecular resonance technology and seeded with mesenchymal stromal cells for tissue engineering esophageal regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- A narrative review of esophageal tissue engineering and replacement: where are we?Annals of translational medicine · 2021Review
- Evaluation of Bilayer Silk Fibroin Grafts for Tubular Esophagoplasty in a Porcine Defect Model.Tissue engineering. Part A · 2021Article
- Regenerative medicine for the upper gastrointestinal tract.Regenerative therapy · 2020Review
- Strategies for treating oesophageal diseases with stem cells.World journal of stem cells · 2020Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue engineering appears promising as an alternative technique for esophageal replacement. Mesenchymal stem cells (MSCs) could be of interest for esophageal regeneration. Evaluation of the ability of an acellular matrix seeded with autologous MSCs to promote tissue remodeling toward an esophageal phenotype after circumferential replacement of the esophagus in a mini pig model. A 3 cm long circumferential replacement of the abdominal esophagus was performed with an MSC-seeded matrix (MSC group, n = 10) versus a matrix alone (control group, n = 10), which has previously been matured into the great omentum. The graft area was covered with an esophageal removable stent. A comparative histological analysis of the graft area after animals were euthanized sequentially is the primary outcome of the study. Histological findings after maturation, overall animal survival, and postoperative morbidity were also compared between groups. At postoperative day 45 (POD 45), a mature squamous epithelium covering the entire surface of the graft area was observed in all the MSC group specimens but in none of the control group before POD 95. Starting at POD 45, desmin positive cells were seen in the graft area in the MSC group but never in the control group. There were no differences between groups in the incidence of surgical complications and postoperative death. In this model, MSCs accelerate the mature re-epitheliazation and early initiation of muscle cell colonization. Further studies will focus on the use of cell tracking tools in order to analyze the becoming of these cells and the mechanisms involved in this tissue regeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.