SynthesisMedicine2017
Is hemoglobin A1c and perioperative hyperglycemia predictive of periprosthetic joint infection following total joint arthroplasty?: A systematic review and meta-analysis.
Synthesis in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- What is the association between insulin dependence and the incidence of postoperative complications, perioperative glucose control, and five-year reoperation rates after total joint replacement?Bone & joint open · 2026Article
- Effect of Failed Debridement, Antibiotics, and Implant Retention on Subsequent Two-Stage Reimplantation for Periprosthetic Joint Infection Following Total Knee Arthroplasty: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Glucagon-Like Peptide-1 Receptor Agonists in Hip and Knee Arthroplasty: A Comprehensive Systematic Review and Meta-Analysis of Perioperative and Postoperative Outcomes.Arthroplasty today · 2026Article
- Debridement, Antibiotics and Implant Retention in the Management of Periprosthetic Joint Infection: One-Year Outcomes, Epidemiology and Predictors of Failure.Journal of clinical medicine · 2026Article
- Outcomes of total knee arthroplasty in people with diabetes: An overview of systematic reviews and meta-analysis.Journal of orthopaedics · 2025Review
- [Diabetes mellitus and total joint arthroplasty-What should be considered?]Orthopadie (Heidelberg, Germany) · 2025Article
- Preventing Infections in Reverse Shoulder Arthroplasty.Current reviews in musculoskeletal medicine · 2024Review
- Preoperative Risk Factors for Periprosthetic Joint Infection: A Narrative Review of the Literature.Healthcare (Basel, Switzerland) · 2024Review
- Higher reinfection rate after two-stage revision arthroplasty in patients with refractory diabetes mellitus: a retrospective analysis with a minimum ten-year follow up.BMC musculoskeletal disorders · 2022Article
- Elective hip arthroplasty rates and related complications in people with diabetes mellitus.Hip international : the journal of clinical and experimental research on hip pathology and therapy · 2022Article
- Association between glycosylated hemoglobin, diabetes mellitus, and preoperative deep vein thrombosis in patients undergoing total joint arthroplasty: a retrospective study.Journal of orthopaedic surgery and research · 2022Article
- Correlation between the Control of Blood Glucose Level and HbA1C and the Incidence of Surgical Site Infection after Emergent Surgery for the Lower Limb Fracture among Type II DM Patients Aged More Than 50 Years Old.Journal of clinical medicine · 2022Article
- Diabetic Kidney Disease Is Associated With Increased Complications Following Operative Management of Ankle Fractures.Foot & ankle orthopaedics · 2022Article
- A1C as a Prognosticator of Perioperative Complications of Diabetes: A Narrative Review.Turkish journal of anaesthesiology and reanimation · 2022Article
- Optimal time period for blood glucose level evaluation after total knee arthroplasty in patients without diabetes: a prospective, observational study.Journal of orthopaedic surgery and research · 2022Observational
- Managing Patients Undergoing Orthopedic Surgery to Improve Glycemic Outcomes.Current diabetes reports · 2022Review
- Total Hip Replacement for Osteoarthritis-Evidence-Based and Patient-Oriented Indications.Deutsches Arzteblatt international · 2021Review
- Failure to Medically Optimize Before Total Hip Arthroplasty: Which Modifiable Risk Factor Is the Most Dangerous?Arthroplasty today · 2021Article
- Observational
- Impact of preoperative HbA1c on postoperative complications after elective major abdominal surgery: a systematic review protocol.BMJ open · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis meta-analysis aims to determine whether hemoglobin A1c (HbA1c) and perioperative hyperglycemia are associated with the increased risk of periprosthetic joint infection following total knee and hip arthroplasty.
methodsA systematic search is performed in Medline (1966-October 2017), PubMed (1966-October 2017), Embase (1980-October 2017), ScienceDirect (1985-October 2017), and the Cochrane Library. Only high-quality studies are selected. A meta-analysis is performed using Stata 11.0 software.
resultsSix retrospective studies including 26,901 patients meet the inclusion criteria. The present meta-analysis indicates that there are significant differences between groups in terms of perioperative random blood glucose level [weighted mean difference (WMD) = 2.365, 95% confidence interval (95% CI): 1.802-2.929, P = .000] and perioperative hemoglobin A1c level (WMD = 3.266, 95% CI: 2.858-3.674, P = .000). No significant difference is found regarding body mass index (BMI) condition between groups (WMD = 0.027, 95% CI: -0.487 to 0.541, P = .919).
conclusionThe present meta-analysis shows that high HbA1c and perioperative hyperglycemia are associated with a higher risk of periprosthetic joint infection following total joint arthroplasty. Screening of HbA1c and perioperative blood glucose is therefore an effective method to predict deep infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.