ArticlePathogens and disease2018
Transcriptional response of Clostridium difficile to low iron conditions.
Article in Pathogens and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
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Who cites it
20 citing papers in PubMed.
- Taxifolin impairs colonization ofMicrobiology spectrum · 2026Article
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- The exploitation of nutrient metals by bacteria for survival and infection in the gut.PLoS pathogens · 2025Review
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- Characterizing the flavodoxin landscape inMicrobiology spectrum · 2024Article
- Characterizing the flavodoxin landscape inMicrobiology spectrum · 2024Article
- Article
- Gut microbiota interspecies interactions shape the response of Clostridioides difficile to clinically relevant antibiotics.PLoS biology · 2023Article
- Iron Effects onAntibiotics (Basel, Switzerland) · 2022Article
- Host and Clostridioides difficile-Response Modulated by Micronutrients and Glutamine: An Overview.Frontiers in nutrition · 2022Review
- Depletion of Lipocalin 2 (LCN2) in Mice Leads to Dysbiosis and Persistent Colonization with Segmented Filamentous Bacteria.International journal of molecular sciences · 2021Article
- Predictive regulatory and metabolic network models for systems analysis of Clostridioides difficile.Cell host & microbe · 2021Article
- The repertoire of ABC proteins inComputational and structural biotechnology journal · 2021Article
- The battle for iron in enteric infections.Immunology · 2020Review
- Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases.Antimicrobial agents and chemotherapy · 2020Article
- Iron Acquisition by Bacterial Pathogens: Beyond Tris-Catecholate Complexes.Chembiochem : a European journal of chemical biology · 2020Review
- ZupT Facilitates Clostridioides difficile Resistance to Host-Mediated Nutritional Immunity.mSphere · 2020Article
- Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Iron Regulation inFrontiers in microbiology · 2018Article
- Pathobionts: mechanisms of survival, expansion, and interaction with host with a focus onGut microbesArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Clostridium difficile (Cd) is the leading cause of antibiotic-associated diarrhea. During an infection, Cd must compete with both the host and other commensal bacteria to acquire iron. Iron is essential for many cell processes, but it can also cause damage if allowed to form reactive hydroxyl radicals. In all organisms, levels of free iron are tightly regulated as are processes utilizing iron molecules. Genome-wide transcriptional analysis of Cd grown in iron-depleted conditions revealed significant changes in expression of genes involved in iron transport, metabolism and virulence. These data will aid future studies examining Cd colonization and the requirements for growth in vivo during an infection.
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