ArticleEndocrinology2018
Three-Dimensional Analysis of the Human Pancreas.
Article in Endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Intra-Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia.Annals of the New York Academy of Sciences · 2026Review
- Preservation of pancreatic endocrine and peri-islet exocrine capillary networks in type 2 diabetes.JCI insight · 2026Article
- Gene Dysregulation and Islet Changes in PDAC-Associated Type 3c Diabetes.International journal of molecular sciences · 2025Article
- Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets.Nature communications · 2025Article
- 3D evaluation of the extracellular matrix of hypoxic pancreatic islets using light sheet fluorescence microscopy.Islets · 2024Article
- Multiscale and multimodal imaging for three-dimensional vascular and histomorphological organ structure analysis of the pancreas.Scientific reports · 2024Article
- Review
- Review
- Geometric and topological characterization of the cytoarchitecture of islets of Langerhans.PLoS computational biology · 2023Article
- Pancreatic regional blood flow links the endocrine and exocrine diseases.The Journal of clinical investigation · 2023Article
- Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.Diabetes · 2023Review
- Pancreas and islet morphology in cystic fibrosis: clues to the etiology of cystic fibrosis-related diabetes.Frontiers in endocrinology · 2023Review
- Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions.Development (Cambridge, England) · 2022Article
- Local islet remodelling associated with duct lesion-islet complex in adult human pancreas.Diabetologia · 2021Article
- Optimizing tissue clearing and imaging methods for human brain tissue.The Journal of international medical research · 2021Article
- Tissue clearing technique: Recent progress and biomedical applications.Journal of anatomy · 2021Review
- Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software.Frontiers in molecular biosciences · 2021Article
- Review
- Pancreas Optical Clearing and 3-D Microscopy in Health and Diabetes.Frontiers in endocrinology · 2021Review
- Capillary Rarefaction in Obesity and Metabolic Diseases-Organ-Specificity and Possible Mechanisms.Cells · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Pancreatic islets are endocrine micro-organs scattered throughout the exocrine pancreas. Islets are surrounded by a network of vasculature, ducts, neurons, and extracellular matrix. Three-dimensional imaging is critical for such structural analyses. We have adapted transparent tissue tomography to develop a method to image thick pancreatic tissue slices (1 mm) with multifluorescent channels. This method takes only 2 to 3 days from specimen preparation and immunohistochemical staining to clearing tissues and imaging. Reconstruction of the intact pancreas visualizes islets with β, α, and δ cells together with their surrounding networks. Capturing several hundred islets at once ensures sufficient power for statistical analyses. Further surface rendering provides clear views of the anatomical relationship between islets and their microenvironment as well as the basis for volumetric quantification. As a proof-of-principle demonstration, we show an islet size-dependent increase of intraislet capillary density and an inverse decrease in sphericity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.