ArticleJournal of food and drug analysis2018
Effects of lemongrass oil and citral on hepatic drug-metabolizing enzymes, oxidative stress, and acetaminophen toxicity in rats.
Article in Journal of food and drug analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 56 citations in OpenAlex.
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- Comparative Study of the Protective Effects of Citral, Thymoquinone, and Silymarin on Methotrexate-induced Cardiotoxicity in Rats.Journal of pharmacopuncture · 2024Article
- Evaluation of the Protective Effect of Citral, Silymarin, and Thymoquinone on Methotrexate-Induced Lung Injury in Rats.Journal of pharmacopuncture · 2023Article
- Synergistic Effect of Diet and Physical Activity on a NAFLD Cohort: Metabolomics Profile and Clinical Variable Evaluation.Nutrients · 2023Article
- Mental Performance and Sport: Caffeine and Co-consumed Bioactive Ingredients.Sports medicine (Auckland, N.Z.) · 2022Review
- Review
- The Effect of Citral on Aquaporin 5 and Trpv4 Expressions and Uterine Contraction in Rat-An Alternative Mechanism.Life (Basel, Switzerland) · 2021Article
- Smell and Stress Response in the Brain: Review of the Connection between Chemistry and Neuropharmacology.Molecules (Basel, Switzerland) · 2021Review
- Effects of citral on serum antioxidant status and liver genes expressions ofIranian journal of veterinary research · 2021Article
- Role of NLRP3 Inflammasome in Lupus Nephritis and Therapeutic Targeting by Phytochemicals.Frontiers in pharmacology · 2021Review
- Effect of citral on mouse hepatic cytochrome P450 enzymes.Pharmaceutical biology · 2018Article
- Ultra-sensitive electrochemical sensing of acetaminophen and codeine in biological fluids using CuO/CuFeJournal of food and drug analysis · 2018Article
- Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Herbal Drugs: Friend or Foe?Journal of clinical and experimental hepatologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The essential oil from a lemongrass variety of Cymbopogon flexuosus [lemongrass oil (LO)] is used in various food and aroma industry products and exhibits biological activities, such as anticancer and antimicrobial activities. To investigate the effects of 200 LO (200 mg/kg) and 400 LO (400 mg/kg) and its major component, citral (240 mg/kg), on drug-metabolizing enzymes, oxidative stress, and acetaminophen toxicity in the liver, male Sprague-Dawley rats were fed a pelleted diet and administered LO or citral by gavage for 2 weeks. After 2 weeks of feeding, the effects of LO and citral on the metabolism and toxicity of acetaminophen were determined. The results showed that rats treated with 400 LO or citral had significantly reduced hepatic testosterone 6β-hydroxylation and ethoxyresorufin O-deethylation activities. In addition, NAD(P)H:quinone oxidoreductase 1 activity was significantly increased by citral, and Uridine 5'-diphospho (UDP) glucurosyltransferase activity was significantly increased by 400 LO in the rat liver. Treatment with 400 LO or citral reduced lipid peroxidation and reactive oxygen species levels in the liver. After acetaminophen treatment, however, LO and citral treatment resulted in little or no change in plasma alanine aminotransferase activity and acetaminophen-protein adducts content in the liver. Our results indicate that LO and citral may change the activities of drug-metabolizing enzymes and reduce oxidative stress in the liver. However, LO and citral may not affect the detoxification of acetaminophen.
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