ArticleJournal of food and drug analysis2018
Selected essential oils inhibit key physiological enzymes and possess intracellular and extracellular antimelanogenic properties in vitro.
Article in Journal of food and drug analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
- Review
- The essential oil extracted with superheated steam extraction from Cinnamomum cassia from Pakistan has potential antimicrobial and antioxidant applications.Scientific reports · 2026Article
- Effect of Chemical Profile on In Vitro Biological Activities of Essential Oils from Southeast MoroccanInternational journal of molecular sciences · 2026Article
- From Waste to Defense: Agro-Industrial Byproducts as Sources of Biopesticides and Bioelicitors for Crop Protection.Journal of agricultural and food chemistry · 2026Review
- FTIR Characterization and Bioactivity Assessment of Cinnamomum camphora Essential Oil: Antioxidant, Anti-Enzymatic, and Antifungal Properties Against Phytopathogens.Chemistry & biodiversity · 2025Article
- Phytochemical Characterization Utilizing HS-SPME/GC-MS: Exploration of the Antioxidant and Enzyme Inhibition Properties of Essential Oil from SaudiPharmaceuticals (Basel, Switzerland) · 2024Article
- Investigating the Potential of Essential Oils fromPlants (Basel, Switzerland) · 2024Article
- Molecular modelling and anticholinesterase activity of the essential oil from three chemotypes ofHeliyon · 2024Article
- Insights onMolecules (Basel, Switzerland) · 2023Article
- Essential Oils: Recent Advances on Their Dual Role as Food Preservatives and Nutraceuticals against the Metabolic Syndrome.Foods (Basel, Switzerland) · 2023Review
- In Vitro and In Silico Pharmacological and Cosmeceutical Potential of Ten Essential Oils from Aromatic Medicinal Plants from the Mascarene Islands.Molecules (Basel, Switzerland) · 2022Article
- Preparation Process Optimization and Performance Characterization of Feed Plant Essential Oil Microcapsules.Molecules (Basel, Switzerland) · 2022Article
- Nitrogen-Containing Heterocyclic Compounds Obtained from Monoterpenes or Their Derivatives: Synthesis and Properties.Topics in current chemistry (Cham) · 2022Review
- Efficacy of Phytochemicals Derived from Roots ofMolecules (Basel, Switzerland) · 2022Article
- Phytochemical Profiling, In Vitro Biological Activities, and In Silico Molecular Docking Studies ofMolecules (Basel, Switzerland) · 2022Article
- Chemical Composition and Cosmeceutical Potential of the Essential Oil ofPlants (Basel, Switzerland) · 2021Article
- Spectral characterization, antioxidant, antimicrobial, cytotoxic, and cyclooxygenase inhibitory activities of Aloysia citriodora essential oils collected from two Palestinian regions.BMC complementary medicine and therapies · 2021Article
- Selected Aspects Related to Medicinal and Aromatic Plants as Alternative Sources of Bioactive Compounds.International journal of molecular sciences · 2021Review
- Essential Oils as Natural Sources of Fragrance Compounds for Cosmetics and Cosmeceuticals.Molecules (Basel, Switzerland) · 2021Review
- Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma.Cancers · 2020Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential oils (EOs) extracted from six medicinal herbs and food plants [Cinnamomum zeylanicum (CZ), Psiadia arguta (PA), Psiadia terebinthina (PT), Citrus grandis (CGp), Citrus hystrix (CH), and Citrus reticulata (CR)] were studied for any inhibitory potential against key physiological enzymes involved in diabetes (α-glucosidase), skin aging (collagenase and elastase), and neurodegenerative disorders (acetylcholinesterase). Kinetic studies of the active EOs on the aforementioned enzymes were determined using Lineweaver-Burk plots. The intracellular and extracellular antimelanogenic potential of the EOs were evaluated on B16F10 mouse melanocytes. CH and CR were found to significantly inhibit (2.476 ± 0.13 μg/mL and 3.636 ± 0.10 μg/mL, respectively) acetylcholinesterase, compared with galantamine (3.989 ± 0.16 μg/mL). CH inhibited collagenase (50% inhibitory concentration 28.71 ± 0.16 μg/mL) compared with the control (24.45 ± 0.19 μg/mL). The percentage inhibition in the elastase assay of CH was 63.21% compared to the positive control (75.09%). In addition, CH, CR, CGp, CZ, and PT were found to significantly inhibit α-glucosidase (276.70 ± 0.73 μg/mL, 169.90 ± 0.58 μg/mL, 240.60 ± 6.50 μg/mL, 64.52 ± 0.69 μg/mL, and 313.0 ± 5.0 μg/mL, respectively), compared to acarbose (448.80 ± 0.81 μg/mL). Active EOs showed both uncompetitive and competitive types of inhibition. The EOs also inhibited intracellular (50% inhibitory concentration 15.92 ± 1.06 μg/mL, 23.75 ± 4.47 μg/mL, and 28.99 ± 5.70 μg/mL for CH, CR, and CGp, respectively) and extracellular (< 15.625 μg/mL for CH, CR, CGp, and PT) melanin production when tested against B16F10 mouse melanocytes. Results from the present study tend to show that EOs extracted from these medicinal plants can inhibit key enzymes and may be potential candidates for cosmetic and pharmaceutical industries.
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