Evidence map›Paper›PMID 29389248›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2018

Role of gp130 in basal and exercise-trained skeletal muscle mitochondrial quality control.

Dennis K Fix, Justin P Hardee, Song Gao, Brandon N VanderVeen, Kandy T Velázquez, James A Carson

Open access · bronzeAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 28 citations in OpenAlex.

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  12. Recovery from FOLFOX chemotherapy-induced systemic and skeletal muscle metabolic dysfunction in mice.American journal of physiology. Endocrinology and metabolism · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dennis K FixIntegrative Muscle Biology Laboratory, Division of Applied Physiology, Department of Exercise Science, University of South Carolina , Columbia, South Carolina.
Justin P HardeeIntegrative Muscle Biology Laboratory, Division of Applied Physiology, Department of Exercise Science, University of South Carolina , Columbia, South Carolina.
Song GaoIntegrative Muscle Biology Laboratory, Division of Applied Physiology, Department of Exercise Science, University of South Carolina , Columbia, South Carolina.
Brandon N VanderVeenIntegrative Muscle Biology Laboratory, Division of Applied Physiology, Department of Exercise Science, University of South Carolina , Columbia, South Carolina.
Kandy T VelázquezIntegrative Muscle Biology Laboratory, Division of Applied Physiology, Department of Exercise Science, University of South Carolina , Columbia, South Carolina.
James A CarsonIntegrative Muscle Biology Laboratory, Division of Applied Physiology, Department of Exercise Science, University of South Carolina , Columbia, South Carolina.
University of South Carolina · US

Funding

TISSUE BIOREPOSITORYP20RR017698 · NCRR · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LAVIGNE, JOHN J · 2002 to 2011
$22.5M
Cachexia in ApcMin/+ mice: The role of IL-6R01CA121249 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CARSON, JAMES A · 2008 to 2018
$2.7M
The effects of Ojeok-san on neuro-immune interactions in cancer-induced visceral painR00AT009206 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI VELAZQUEZ, KANDY T · 2019 to 2021
$747k
The effects of Ojeok-san on neuro-immune interactions in cancer-induced visceral painK99AT009206 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI VELAZQUEZ, KANDY T · 2017 to 2018
$199k
NCCIH NIH HHS K99 AT009206NCCIH NIH HHS R00 AT009206NCI NIH HHS R01 CA121249NCRR NIH HHS P20 RR017698
6 · The paper itself

Abstract

The IL-6 cytokine family activates intracellular signaling pathways through glycoprotein-130 (gp130), and this signaling has established regulatory roles in muscle glucose metabolism and proteostasis. Although the IL-6 family has been implicated as myokines regulating the muscles' metabolic response to exercise, gp130's role in mitochondrial quality control involving fission, fusion, mitophagy, and biogenesis is not well understood. Therefore, we examined gp130's role in basal and exercise-trained muscle mitochondrial quality control. Muscles from C57BL/6, skeletal muscle-specific gp130 knockout (KO) mice, and C

Indexed as

AnimalsAutophagyCytokine Receptor gp130MaleMice, Inbred C57BLMice, KnockoutMitochondria, MusclePhysical Conditioning, AnimalCytokine Receptor gp130Il6st protein, mouseendurance trainingIL-6mitochondriaSTAT3

Identifiers

PMID29389248
PMCPMC6032094
OpenAlexW2786047813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.