Evidence map›Paper›PMID 29389054›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2018

Streamlined Synthesis and Evaluation of Teichoic Acid Fragments.

Daan van der Es, Francesca Berni, Wouter F J Hogendorf, Nico Meeuwenoord, Diana Laverde, Angela van Diepen, Herman S Overkleeft, Dmitri V Filippov, Cornelis H Hokke, Johannes Huebner and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. The molecular architecture ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Antibody Recognition of DifferentACS central science · 2022
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Generation of glucosylatedRSC chemical biology · 2021
    Article
  11. Review
  12. Article
  13. Review
  14. Streamlined Synthesis and Evaluation of Teichoic Acid Fragments.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Daan van der EsLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333, CC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-3662-8177
Francesca BerniLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333, CC, Leiden, The Netherlands.
Wouter F J HogendorfLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333, CC, Leiden, The Netherlands.
Nico MeeuwenoordLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333, CC, Leiden, The Netherlands.
Diana LaverdeDivision of Paediatric Infectious Diseases, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.
Angela van DiepenDepartment of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Herman S OverkleeftLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333, CC, Leiden, The Netherlands.
Dmitri V FilippovLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333, CC, Leiden, The Netherlands.
Cornelis H HokkeDepartment of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Johannes HuebnerDivision of Paediatric Infectious Diseases, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.
Gijsbert A van der MarelLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333, CC, Leiden, The Netherlands.
Jeroen D C CodéeLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333, CC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-3531-2138
Leiden University · NLLeiden University Medical Center · NLLudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Teichoic acids (TAs) are key components of the Gram-positive bacterial cell wall that are composed of alditol phosphate repeating units, decorated with alanine or carbohydrate appendages. Because of their microhetereogeneity, pure well-defined TAs for biological or immunological evaluation cannot be obtained from natural sources. We present here a streamlined automated solid-phase synthesis approach for the rapid generation of well-defined glycosylated, glycerol-based TA oligomers. Building on the use of a "universal" linker system and fluorous tag purification strategy, a library of glycerolphosphate pentadecamers, decorated with various carbohydrate appendages, is generated. These are used to create a structurally diverse TA-microarray, which is used to reveal, for the first time, the binding preferences of anti-LTA (lipoteichoic acids) antibodies at the molecular level.

Indexed as

AlanineCell WallGlycosylationGram-Positive BacteriaLipopolysaccharidesMolecular StructureSolid-Phase Synthesis TechniquesSugar AlcoholsTeichoic AcidsAlanineLipopolysaccharideslipoteichoic acidSugar AlcoholsTeichoic Acidsautomated synthesisglycerol phosphateGram-positive bacteriamicroarraysoligomers

Identifiers

PMID29389054
PMCPMC5887911
OpenAlexW2789520107

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.