Evidence map›Paper›PMID 29388912›Full record

ArticleeLife2018

Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis.

David V Phizicky, Luke E Berchowitz, Stephen P Bell

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Decoding Cdk1 control: from mitotic thresholds to meiotic specificity.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
    Review
  2. An Orc6 tether mediates ORC binding-site switching during replication origin licensing.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
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  7. Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Cadmium Sulfide Quantum Dots Adversely Affect Gametogenesis inNanomaterials (Basel, Switzerland) · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Budding yeast relies on GScience advances · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

David V PhizickyDepartment of Biology, Massachusetts Institute of Technology, Cambridge, United States.ORCID http://orcid.org/0000-0002-4219-702X
Luke E BerchowitzDepartment of Genetics and Development, Columbia University Medical Center, New York, United States.
Stephen P BellDepartment of Biology, Massachusetts Institute of Technology, Cambridge, United States.ORCID http://orcid.org/0000-0002-2876-610X
Howard Hughes Medical Institute · USColumbia University Irving Medical Center · US

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Paula T Hammond · 1985 to 2026
$93.9M
PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Elucidation of regulation and function of amyloid-like assembliesR35GM124633 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Luke E Berchowitz · 2017 to 2026
$4.2M
Howard Hughes Medical Institute Investigator AwardNCI NIH HHS Biopolymer Facility SupportNCI NIH HHS P30 CA014051NIGMS NIH HHS Gradaute Student FellowshipNIGMS NIH HHS R35 GM124633NIGMS NIH HHS T32 GM007287
6 · The paper itself

Abstract

Meiotic cells undergo a single round of DNA replication followed by two rounds of chromosome segregation (the meiotic divisions) to produce haploid gametes. Both DNA replication and chromosome segregation are similarly regulated by CDK oscillations in mitotic cells. Yet how these two events are uncoupled between the meiotic divisions is unclear. Using

Indexed as

Chromosome SegregationDNA ReplicationMeiosisCyclin-Dependent KinasesDNA HelicasesGene Regulatory NetworksIntracellular Signaling Peptides and ProteinsProtein Interaction MapsProtein Serine-Threonine KinasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCyclin-Dependent KinasesDNA HelicasesIME2 protein, S cerevisiaeIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesSaccharomyces cerevisiae ProteinsCdc6chromosomesDNA ReplicationgenesIme2Mcm2-7meiosisS. cerevisiaeSld2

Identifiers

PMID29388912
PMCPMC5805409
OpenAlexW2787460243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.