Evidence map›Paper›PMID 29388837›Full record

ArticleCancer investigation2018

Adenovirus Lacking E1b Efficiently Induces Cytopathic Effect in HPV-16-Positive Murine Cancer Cells via Virus Replication and Apoptosis.

Elvis Martinez-Jaramillo, Rodolfo Garza-Morales, Stephen L Wechman, Roberto Montes de Oca-Luna, Odila Saucedo-Cardenas, Haval Shirwan, Esma Yolcu, Kelly M McMasters, Jorge G Gomez-Gutierrez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Elvis Martinez-Jaramilloa The Hiram C. Polk Jr., MD, Department of Surgery , University of Louisville School of Medicine , Louisville , USA.
Rodolfo Garza-Moralesa The Hiram C. Polk Jr., MD, Department of Surgery , University of Louisville School of Medicine , Louisville , USA.
Stephen L Wechmana The Hiram C. Polk Jr., MD, Department of Surgery , University of Louisville School of Medicine , Louisville , USA.
Roberto Montes de Oca-Lunab Department of Histology, School of Medicine , Autonomous University of Nuevo León , Monterrey , N.L. México.
Odila Saucedo-Cardenasb Department of Histology, School of Medicine , Autonomous University of Nuevo León , Monterrey , N.L. México.
Haval Shirwanc Department of Microbiology and Immunology, Institute for Cellular Therapeutics , University of Louisville , Louisville , USA.
Esma Yolcuc Department of Microbiology and Immunology, Institute for Cellular Therapeutics , University of Louisville , Louisville , USA.
Kelly M McMastersa The Hiram C. Polk Jr., MD, Department of Surgery , University of Louisville School of Medicine , Louisville , USA.
Jorge G Gomez-Gutierreza The Hiram C. Polk Jr., MD, Department of Surgery , University of Louisville School of Medicine , Louisville , USA.ORCID http://orcid.org/0000-0003-3610-260X
University of Louisville · USMexican Social Security Institute · MXUniversidad Autónoma de Nuevo León · MX

Funding

Targeting melanoma hypoxia with lactic acid bacterium L. lactisR21CA210202 · NCI · UNIVERSITY OF LOUISVILLE · PI GOMEZ-GUTIERREZ, JORGE G · 2017 to 2018
$368k
NCI NIH HHS R21 CA210202
6 · The paper itself

Abstract

Conditionally replicative adenoviruses (CRAds) replicate poorly in murine cancer cells; however, E1b-deleted CRAds may replicate effectively in HPV16-E6/E7-positive murine cancer cells (TC-1). The HPV16 E7 open reading frame encodes functions analogous to these deleted adenovirus E1 proteins. In this study, an E1b-deleted CRAd (Adhz60) was evaluated for its ability to replicate and induce oncolysis in TC-1 cells. Adhz60-mediated oncolysis was similar in TC-1 and HeLa cells. Productive viral replication was evident based on expression of E1A and hexon, production of infectious virus progeny, and Adhz60-induced apoptosis. The results suggest that TC-1 murine cancer cells allow Adhz60 replication and oncolysis.

Indexed as

AdenoviridaeAdenovirus E1B ProteinsAnimalsApoptosisCell Line, TumorHEK293 CellsHeLa CellsHuman papillomavirus 16HumansMiceMice, Inbred C57BLOncogene Proteins, ViralPapillomavirus E7 ProteinsRepressor ProteinsVirus ReplicationAdenovirus E1B ProteinsE6 protein, Human papillomavirus type 16oncogene protein E7, Human papillomavirus type 16Oncogene Proteins, ViralPapillomavirus E7 ProteinsRepressor ProteinsAdenovirusApoptosisHPV16OncolysisReplication

Identifiers

PMID29388837
PMCPMC6088374
OpenAlexW2793148747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.