ArticleOrganic letters2018
Premutilin Synthase: Ring Rearrangement by a Class II Diterpene Cyclase.
Article in Organic letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Bioinspired total synthesis of (+)-pleuromutilin.Nature communications · 2026Article
- Exploring a Unique Class II Diterpene Cyclase: The Modified Catalytic Acid Motif Contributes to Ring Contraction in Premutilin Synthase.Organic letters · 2026Article
- Ring contraction and ring expansion reactions in terpenoid biosynthesis and their application to total synthesis.Beilstein journal of organic chemistry · 2026Review
- Transformation of the cyclohexane ring to the cyclopentane fragment of biologically active compounds.Beilstein journal of organic chemistry · 2025Review
- Class II terpene cyclases: structures, mechanisms, and engineering.Natural product reports · 2024Review
- Biosynthesis of pleuromutilin congeners using anChemical science · 2023Article
- Plant (di)terpenoid evolution: from pigments to hormones and beyond.Natural product reports · 2023Review
- Functional Characterization of Three Diterpene Synthases Responsible for Tetracyclic Diterpene Biosynthesis inPlants (Basel, Switzerland) · 2022Article
- Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase.Journal of the American Chemical Society · 2022Article
- Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement.Journal of the American Chemical Society · 2022Article
- Biosynthesis and regulation of terpenoids from basidiomycetes: exploration of new research.AMB Express · 2021Review
- Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi.Applied microbiology and biotechnology · 2021Article
- Magnesium-specific ring expansion/contraction catalysed by the class II diterpene cyclase from pleuromutilin biosynthesis.Organic & biomolecular chemistry · 2020Article
- Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases.Metabolic engineering · 2019Article
- Catalytic Bases and Stereocontrol in Lamiaceae Class II Diterpene Cyclases.Biochemistry · 2018Article
- Changing Face: A Key Residue for the Addition of Water by Sclareol Synthase.ACS catalysis · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
Biosynthesis of the complex diterpenoid antibiotic pleuromutilin relies on a bifunctional (di)terpene synthase, and here site-directed mutagenesis was used to knockout either of the two active sites. This enabled characterization of the novel ring contracted intermediate produced by the initiating class II diterpene cyclase active site. Quantum chemical calculations further indicate the importance of reactant configuration for this intriguing ring rearrangement.
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