Evidence map›Paper›PMID 29388719›Full record

ArticleNMR in biomedicine2018

Multi-compartmental diffusion characterization of the human cervical spinal cord in vivo using the spherical mean technique.

Samantha By, Junzhong Xu, Bailey A Box, Francesca R Bagnato, Seth A Smith

Abstract read
In one paragraph

Article in NMR in biomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. AJNR. American journal of neuroradiology · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Challenges for biophysical modeling of microstructure.Journal of neuroscience methods · 2020
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Probing axons using multi-compartmental diffusion in multiple sclerosis.Annals of clinical and translational neurology · 2019
    Article
  20. Advances in spinal cord imaging in multiple sclerosis.Therapeutic advances in neurological disorders · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samantha ByDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-8158-2732
Junzhong XuDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
Bailey A BoxVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Francesca R BagnatoDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-9544-9019
Seth A SmithDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.

Funding

MRI Diffusion in Tumors Using Oscillating GradientsR01CA109106 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI XU, JUNZHONG · 2006 to 2022
$4.0M
Microstructural Characterization of the Optic Nerve in Optic NeuritisR01EY023240 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SMITH, SETH A · 2014 to 2017
$1.0M
In Vivo Macromolecular and Protein-Based MRI in the Spinal Cord of MS PatientsR21NS087465 · NINDS · VANDERBILT UNIVERSITY · PI SMITH, SETH A · 2014 to 2015
$431k
NCI NIH HHS R01 CA109106NEI NIH HHS R01 EY023240NINDS NIH HHS R21 NS087465
6 · The paper itself

Abstract

The purpose of this work was to evaluate the feasibility and reproducibility of the spherical mean technique (SMT), a multi-compartmental diffusion model, in the spinal cord of healthy controls, and to assess its ability to improve spinal cord characterization in multiple sclerosis (MS) patients at 3 T. SMT was applied in the cervical spinal cord of eight controls and six relapsing-remitting MS patients. SMT provides an elegant framework to model the apparent axonal volume fraction v

Indexed as

Diffusion Magnetic Resonance ImagingAdultCervical CordCohort StudiesHumansMultiple SclerosisReproducibility of Resultsaxondiffusionmultiple sclerosisspherical mean techniquespinal cordvolume fraction

Identifiers

PMID29388719
PMCPMC5854548

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.