ArticleJournal of neural engineering2018
Optimization of pillar electrodes in subretinal prosthesis for enhanced proximity to target neurons.
Article in Journal of neural engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 1 citations in OpenAlex.
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- Photovoltaic Stimulation of Mouse and Pig Retina With Pyrolytic Carbon Microelectrodes Integrated on High-Density Silicon Solar Cell Arrays.Advanced healthcare materials · 2026Article
- Maximizing the fidelity of a photovoltaic subretinal prosthesis for human patients.Journal of neural engineering · 2026Article
- Review of Recent Advances in Implantable Brain-Computer Interfaces for the Restoration of Motor Function in Patients With Paralysis.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Advances in Electrode Design and Physiological Considerations for Retinal Implants.Micromachines · 2025Review
- Electrical stimulation of neuroretinas with 3D pyrolytic carbon electrodes.Biomedical microdevices · 2025Article
- Liquid-metal-based three-dimensional microelectrode arrays integrated with implantable ultrathin retinal prosthesis for vision restoration.Nature nanotechnology · 2024Article
- Three-dimensional electro-neural interfaces electroplated on subretinal prostheses.Journal of neural engineering · 2024Article
- Fabrication and Validation of Sub-Cellular Carbon Fiber Electrodes.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2024Article
- Three-dimensional electro-neural interfaces electroplated on subretinal prostheses.bioRxiv : the preprint server for biology · 2023Article
- Retinal Prostheses: Engineering and Clinical Perspectives for Vision Restoration.Sensors (Basel, Switzerland) · 2023Review
- Direct laser writing of 3D electrodes on flexible substrates.Nature communications · 2023Article
- Integrated Low-Voltage Compliance and Wide-Dynamic Stimulator Design for Neural Implantable Devices.Sensors (Basel, Switzerland) · 2023Article
- Pixel size limit of the PRIMA implants: from humans to rodents and back.Journal of neural engineering · 2022Article
- Micro-magnetic stimulation of primary visual cortex induces focal and sustained activation of secondary visual cortex.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Article
- Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation.Frontiers in cellular neuroscience · 2022Article
- Artificial Visual Information Produced by Retinal Prostheses.Frontiers in cellular neuroscience · 2022Review
- Structural changes in the retina after implantation of subretinal three-dimensional implants in mini pigs.Frontiers in neuroscience · 2022Article
- A flexible protruding microelectrode array for neural interfacing in bioelectronic medicine.Microsystems & nanoengineering · 2022Article
- The impact of synchronous versus asynchronous electrical stimulation in artificial vision.Journal of neural engineering · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveHigh-resolution prosthetic vision requires dense stimulating arrays with small electrodes. However, such miniaturization reduces electrode capacitance and penetration of electric field into tissue. We evaluate potential solutions to these problems with subretinal implants based on utilization of pillar electrodes. APPROACH: To study integration of three-dimensional (3D) implants with retinal tissue, we fabricated arrays with varying pillar diameter, pitch, and height, and implanted beneath the degenerate retina in rats (Royal College of Surgeons, RCS). Tissue integration was evaluated six weeks post-op using histology and whole-mount confocal fluorescence imaging. The electric field generated by various electrode configurations was calculated in COMSOL, and stimulation thresholds assessed using a model of network-mediated retinal response. MAIN
resultsRetinal tissue migrated into the space between pillars with no visible gliosis in 90% of implanted arrays. Pillars with 10 μm height reached the middle of the inner nuclear layer (INL), while 22 μm pillars reached the upper portion of the INL. Electroplated pillars with dome-shaped caps increase the active electrode surface area. Selective deposition of sputtered iridium oxide onto the cap ensures localization of the current injection to the pillar top, obviating the need to insulate the pillar sidewall. According to computational model, pillars having a cathodic return electrode above the INL and active anodic ring electrode at the surface of the implant would enable six times lower stimulation threshold, compared to planar arrays with circumferential return, but suffer from greater cross-talk between the neighboring pixels. SIGNIFICANCE: 3D electrodes in subretinal prostheses help reduce electrode-tissue separation and decrease stimulation thresholds to enable smaller pixels, and thereby improve visual acuity of prosthetic vision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.