Evidence map›Paper›PMID 29388419›Full record

ArticleAnalytical chemistry2018

GABA Detection with Nano-ITIES Pipet Electrode: A New Mechanism, Water/DCE-Octanoic Acid Interface.

Nicholas Toshio Iwai, Michelle Kramaric, Daniel Crabbe, Yuanyuan Wei, Ran Chen, Mei Shen

Abstract read
In one paragraph

Article in Analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 61 citations in OpenAlex.

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  13. Nanoelectrochemistry in the study of single-cell signaling.Analytical and bioanalytical chemistry · 2020
    Review
  14. Article
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  16. Electrochemistry at the Synapse.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nicholas Toshio IwaiDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Mathews Avenue , Urbana , Illinois 61801 , United States.
Michelle KramaricDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Mathews Avenue , Urbana , Illinois 61801 , United States.
Daniel CrabbeDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Mathews Avenue , Urbana , Illinois 61801 , United States.
Yuanyuan WeiDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Mathews Avenue , Urbana , Illinois 61801 , United States.
Ran ChenDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Mathews Avenue , Urbana , Illinois 61801 , United States.
Mei ShenDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Mathews Avenue , Urbana , Illinois 61801 , United States.ORCID 0000-0002-6033-8308
University of Illinois Urbana-Champaign · US

Funding

Study Exocytosis in the Region of Synaptic Cleft using Electrochemical NanoprobeR21NS085665 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SHEN, MEI · 2013 to 2014
$391k
NINDS NIH HHS R21 NS085665
6 · The paper itself

Abstract

Interface between two immiscible electrolyte solutions (ITIES) supported on the orifice of a pipet have become a powerful platform to detect a broad range of analytes. We present here the detection of γ-aminobutyric acid (GABA) with the nanoITIES pipet electrodes for the first time. GABA has a net charge of zero in an aqueous solution at pH ≈ 7, and it has not previously been detected at ITIES. In this work, we demonstrated GABA detection at ITIES in an aqueous solution at pH ≈ 7, where we introduced a novel detection strategy based on "pH modulation from the oil phase". To the best of our knowledge, this is the first report of such. Current increases linearly with increasing concentrations of GABA, ranging from 0.25 mM to 1.0 mM. The measured half-wave transfer potential of GABA is -0.401 ± 0.010 V ( n = 22) vs E

Indexed as

CaprylatesElectrochemical TechniquesElectrodesEthylene Dichloridesgamma-Aminobutyric AcidHydrogen-Ion ConcentrationLimit of DetectionProtonsWaterCaprylatesethylene dichlorideEthylene Dichloridesgamma-Aminobutyric Acidoctanoic acidProtonsWater

Identifiers

PMID29388419
PMCPMC6126903
OpenAlexW2785836443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.