Evidence map›Paper›PMID 29388275›Full record

Trial reportPsycho-oncology2018

A randomized dose-response trial of aerobic exercise and health-related quality of life in colon cancer survivors.

Justin C Brown, Nevena Damjanov, Kerry S Courneya, Andrea B Troxel, Babette S Zemel, Michael R Rickels, Bonnie Ky, Andrew D Rhim, Anil K Rustgi, Kathryn H Schmitz

Abstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psycho-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 17 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 17 syntheses or guidelines pooled it, 103 citations in OpenAlex.

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  7. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  13. Effectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Justin C BrownDana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0001-7540-4913
Nevena DamjanovUniversity of Pennsylvania, Philadelphia, PA, USA.
Kerry S CourneyaUniversity of Alberta, Edmonton, Alberta, Canada.
Andrea B TroxelNew York University, New York, NY, USA.
Babette S ZemelUniversity of Pennsylvania, Philadelphia, PA, USA.
Michael R RickelsUniversity of Pennsylvania, Philadelphia, PA, USA.
Bonnie KyUniversity of Pennsylvania, Philadelphia, PA, USA.
Andrew D RhimMD Anderson Cancer Center, Houston, TX, USA.
Anil K RustgiUniversity of Pennsylvania, Philadelphia, PA, USA.
Kathryn H SchmitzPenn State College of Medicine, Hershey, PA, USA.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USDana-Farber Cancer Institute · USNew York University · USPenn State Milton S. Hershey Medical Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Alberta · CA

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI JOSHUA D RABINOWITZ · 1986 to 2026
$48.3M
The Women In Steady Exercise Research (WISER) SurwVor TrialU54CA155850 · NCI · UNIVERSITY OF PENNSYLVANIA · PI TROXEL, ANDREA B · 2011 to 2015
$9.1M
The COURAGE Trial: Colon Recurrence and Aerobic Exercise: A Feasibility StudyR21CA182767 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SCHMITZ, KATHRYN H. · 2014 to 2015
$377k
Inflammation, Physical Activity, and Colon Cancer Recurrence and SurvivalK99CA218603 · NCI · DANA-FARBER CANCER INST · PI BROWN, JUSTIN C · 2017 to 2018
$260k
Effects of Exercise on Visceral Adiposity & Hyperinsulinemia in Colon Cancer SurvivorF31CA192560 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BROWN, JUSTIN C · 2015 to 2016
$69k
NCI NIH HHS F31 CA192560NCI NIH HHS K99 CA218603NCI NIH HHS R21 CA182767NCI NIH HHS U54 CA155850NIDDK NIH HHS P30 DK019525
6 · The paper itself

Abstract

objectiveTo examine the dose-response effects of aerobic exercise on health-related quality of life (HRQoL) among colon cancer survivors.

methodsThirty-nine stage I to III colon cancer survivors were randomized to 1 of 3 groups: usual-care control, 150 min·wk

resultsOver 6 months, the low-dose group completed 141 ± 10 min·wk

conclusionHigher doses of aerobic exercise, up to 300 min·wk

Indexed as

Quality of LifeCancer SurvivorsColonic NeoplasmsExerciseExercise TherapyFatigueFemaleHealth StatusHumansMaleMiddle AgedPatient Reported Outcome Measurescanceroncologypatient-reported outcomephysical activity, physical function, survivorship, wellness

Identifiers

PMID29388275
PMCPMC5895514
OpenAlexW2790205296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.