Evidence map›Paper›PMID 29388265›Full record

ArticleMolecular microbiology2018

The curli regulator CsgD mediates stationary phase counter-silencing of csgBA in Salmonella Typhimurium.

S L Newman, W R Will, S J Libby, F C Fang

Open access · bronzeAbstract read
In one paragraph

Article in Molecular microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Deletion of theGut microbes · 2020
    Article
  9. Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  10. Transcription of Bacterial Chromatin.Journal of molecular biology · 2019
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

S L NewmanMolecular and Cellular Biology Program, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2008-948X
W R WillDepartment of Microbiology, University of Washington, Seattle WA, USA.
S J LibbyDepartment of Microbiology, University of Washington, Seattle WA, USA.
F C FangDepartment of Laboratory Medicine, University of Washington, Seattle, WA, USA.
University of Washington · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
Typhoid Pathogenesis and ImmunityR01AI112640 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2015 to 2019
$2.1M
Antimicrobial Actions of Nitric OxideR01AI118962 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2016 to 2020
$1.9M
Silencing and Counter-Silencing of Salmonella Virulence GenesR01AI101084 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2012 to 2015
$1.5M
NIAID NIH HHS R01 AI101084NIAID NIH HHS R01 AI112640NIAID NIH HHS R01 AI118962NIGMS NIH HHS T32 GM007270
6 · The paper itself

Abstract

Integration of horizontally acquired genes into transcriptional networks is essential for the regulated expression of virulence in bacterial pathogens. In Salmonella enterica, expression of such genes is repressed by the nucleoid-associated protein H-NS, which recognizes and binds to AT-rich DNA. H-NS-mediated silencing must be countered by other DNA-binding proteins to allow expression under appropriate conditions. Some genes that can be transcribed by RNA polymerase (RNAP) associated with the alternative sigma factor σ

Indexed as

Gene SilencingBacterial ProteinsDNA-Binding ProteinsDNA-Directed RNA PolymerasesFimbriae, BacterialGene Expression Regulation, BacterialOperonPromoter Regions, GeneticSalmonella typhimuriumSigma FactorTrans-ActivatorsTranscription, GeneticVirulenceBacterial ProteinsDNA-Binding ProteinsDNA-Directed RNA PolymerasesH-NS protein, bacteriaSigma FactorTrans-Activators

Identifiers

PMID29388265
PMCPMC5867262
OpenAlexW2794328591

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.