Evidence map›Paper›PMID 29388085›Full record

Trial reportClinical rheumatology2018

Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis.

Ke Su, Yuming Bai, Jun Wang, Haisen Zhang, Hao Liu, Shiyun Ma

2 registry-linked trialsAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 79 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 22 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06707948 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Comparison of Different Treatment Strategies for Root Injury Behind the Medial Meniscus to Delay the Progression of Knee Osteoarthritis: a Prospective Cohort Study

TypeobservationalSponsorShanghai General Hospital, Shanghai Jiao Tong University School of MedicineRan2024 to 2027Enrolled69ConditionsOsteoarthritis, Meniscus LesionArmsArthroscopic meniscus surgery
NCT07016672 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Therapy With Intra-articular Injections of PRP Compared With Therapy With Intra-articular Injections of HA, in Patients With Grade III or IV GONArthrosis: a Prospective Randomized Open-label Study

TypeinterventionalSponsorCentre Hospitalier Intercommunal de Toulon La Seyne sur MerRan2025 to 2028Enrolled150ConditionsKnee OsteoarthritisArmsintra-articular injection of HA, intra-articular injection of PRP
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 22 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Pooled it
  19. Pooled it
  20. Pooled it

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ke SuArthroscopic Surgery Unit, Orthopaedic Surgery Department, Cangzhou Central Hospital, Cangzhou Shi, Hebei Province, 061001, China. sukeyx@163.com.
Yuming BaiArthroscopic Surgery Unit, Orthopaedic Surgery Department, Cangzhou Central Hospital, Cangzhou Shi, Hebei Province, 061001, China.
Jun WangArthroscopic Surgery Unit, Orthopaedic Surgery Department, Cangzhou Central Hospital, Cangzhou Shi, Hebei Province, 061001, China.
Haisen ZhangArthroscopic Surgery Unit, Orthopaedic Surgery Department, Cangzhou Central Hospital, Cangzhou Shi, Hebei Province, 061001, China.
Hao LiuBlood Test Unit, Laboratory Department, Cangzhou Central Hospital, Cangzhou Shi, Hebei Province, China.
Shiyun MaArthroscopic Surgery Unit, Orthopaedic Surgery Department, Cangzhou Central Hospital, Cangzhou Shi, Hebei Province, 061001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to evaluate the benefit provided by intraosseous infiltration combined with intra-articular injection of platelet-rich plasma to treat mild and moderate stages of knee joint degeneration (Kellgren-Lawrence score II-III) compared with other treatments, specifically intra-articular injection of PRP and of HA. Eighty-six patients with grade II to grade III knee OA according to the Kellgren-Lawrence classification were randomly assigned to intra-articular combined with intraosseous injection of PRP (group A), intra-articular PRP (group B), or intra-articular HA (group C). Patients in group A received intra-articular combined with intraosseous injection of PRP (administered twice, 2 weeks apart). Patients in group B received intra-articular injection of PRP every 14 days. Patients in group C received a series of five intra-articular injections of HA every 7 days. All patients were evaluated using the Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities (WOMAC) score before the treatment and at 1, 3, 6, 12, and 18 months after treatment. There were significant improvements at the end of the 1st month. Notably, group A patients had significantly superior VAS and WOMAC scores than were observed in groups B and C. The VAS scores were similar in groups B and group C after the 6th month. Regarding the WOMAC scores, groups B and C differed at the 1st, 3rd, 6th, and 12th months; however, no significant difference was observed at the 18th month. The combination of intraosseous with intra-articular injections of PRP resulted in a significantly superior clinical outcome, with sustained lower VAS and WOMAC scores and improvement in quality of life within 18 months.

Indexed as

Platelet-Rich PlasmaAdultAgedCombined Modality TherapyFemaleHumansHyaluronic AcidInjections, Intra-ArticularKnee JointMaleMiddle AgedOsteoarthritis, KneeQuality of LifeTreatment OutcomeHyaluronic AcidHyaluronic acidIntra-articular injectionKnee osteoarthritisPlatelet-rich plasma

Identifiers

PMID29388085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.