Evidence map›Paper›PMID 29388067›Full record

ReviewMolecular diagnosis & therapy2018

Oncogenic and Tumor-Suppressive Roles of MicroRNAs with Special Reference to Apoptosis: Molecular Mechanisms and Therapeutic Potential.

Dharambir Kashyap, Hardeep Singh Tuli, Vivek Kumar Garg, Neelam Goel, Anupam Bishayee

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular diagnosis & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
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  4. Article
  5. Advancing the frontiers of colorectal cancer treatment: harnessing ferroptosis regulation.Apoptosis : an international journal on programmed cell death · 2024
    Review
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  7. Article
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  9. Article
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  14. Article
  15. Observational
  16. Review
  17. Exosome-enriched fractions from MS B cells induce oligodendrocyte death.Neurology(R) neuroimmunology & neuroinflammation · 2019
    Article
  18. Review
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Dharambir KashyapDepartment of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, Punjab, India.
Hardeep Singh TuliDepartment of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, 133207, Haryana, India. hardeep.biotech@gmail.com.
Vivek Kumar GargDepartment of Biochemistry, Government Medical College and Hospital, Chandigarh, 160030, Punjab, India.
Neelam GoelDepartment of Information Technology, University Institute of Engineering and Technology, Panjab University, Chandigarh, 160014, Punjab, India.
Anupam BishayeeDepartment of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL, 33169, USA. abishayee@ularkin.org.
Government Medical College and Hospital · INLarkin University · USMaharishi Markandeshwar University, Mullana · INPanjab University · INPost Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are the non-coding class of minute RNA molecules that negatively control post-transcriptional regulation of various functional genes. These miRNAs are transcribed from the loci present in the introns of functional or protein-coding genes, exons of non-coding genes, or even in the 3'-untranslated region (3'-UTR). They have potential to modulate the stability or translational efficiency of a variety of target RNA [messenger RNA (mRNA)]. The regulatory function of miRNAs has been elucidated in several pathological conditions, including neurological (Alzheimer's disease and Parkinson's disease) and cardiovascular conditions, along with cancer. Importantly, miRNA identification in cancer progression and invasion has evolved as an incipient era in cancer treatment. Several studies have shown the influence of miRNAs on various cancer processes, including apoptosis, invasion, metastasis and angiogenesis. In particular, apoptosis induction in tumor cells through miRNA has been extensively studied. The biphasic mode (up- and down-regulation) of miRNA expression in apoptosis and other cancer processes has already been determined. The findings of these studies could be utilized to develop potential therapeutic strategies for the management of various cancers. The present review critically describes the oncogenic and tumor suppressor role of miRNAs in apoptosis and other cancer processes, therapy resistance, and use of their presence in the body fluids as biomarkers.

Indexed as

Genes, Tumor SuppressorOncogenesApoptosisBiomarkers, TumorBody FluidsHumansMicroRNAsBiomarkers, TumorMicroRNAs

Identifiers

PMID29388067
OpenAlexW2788272058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.