ArticleEndocrine2018
Longitudinal AddiQoL scores may identify higher risk for adrenal crises in Addison's disease.
Article in Endocrine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Health-related quality of life and patterns of psychological vulnerability in autoimmune Addison's disease: a systematic review.Frontiers in endocrinology · 2026Pooled it
- Prednisolone Once Daily vs Hydrocortisone Thrice Daily in Hypoadrenalism: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Risk and outcomes of adrenal crisis in primary adrenal insufficiency: Evidence from a 24-year nationwide cohort study.Journal of internal medicine · 2026Article
- Adrenal crises and quality of life after bilateral adrenalectomy vs primary autoimmune adrenal insufficiency.Journal of the Endocrine Society · 2026Article
- Group education improves self-management of adrenal insufficiency in patients and their relative.Endocrine connections · 2026Article
- Adrenal crisis: incidence, clinical presentation and risk factors in patients with Addison's disease.Endocrine · 2025Article
- Health-Related Quality of Life in Patients with Primary Adrenal Insufficiency.Journal of clinical medicine · 2023Article
- Editorial: Primary Adrenal Insufficiency - Quality of Life and Long-Term Outcome With Current Treatment Strategies.Frontiers in endocrinology · 2022Article
- Impact of COVID-19 pandemic on psychophysical stress in patients with adrenal insufficiency: the CORTI-COVID study.Journal of endocrinological investigation · 2021Article
- Determinants of Self-reported Health Outcomes in Adrenal Insufficiency: A Multisite Survey Study.The Journal of clinical endocrinology and metabolism · 2021Article
- Therapeutic Patient Education for Adrenal Insufficiency under COVID-19 Pandemic Conditions.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2021Review
- Clinical Unmet Needs in the Treatment of Adrenal Crisis: Importance of the Patient's Perspective.Frontiers in endocrinology · 2021Review
- Sex-Specific Limitations in Physical Health in Primary Adrenal Insufficiency.Frontiers in endocrinology · 2021Article
- Adrenal crisis: prevention and management in adult patients.Therapeutic advances in endocrinology and metabolism · 2019Review
- Does quality of life differ in patients with Addison's disease on different glucocorticoid therapies?Endocrine · 2018Article
- Predicting an adrenal crisis: can we do it?Endocrine · 2018Article
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5 authors at 1 institution in 1 country.
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Abstract
purposeSeveral studies have shown a reduced quality of life (QoL) in patients with Addison's disease (AD), but investigations of QoL over a long-term course are lacking. Adrenal crises (AC) are life-threatening complications in AD. The purpose of this prospective study was to test whether the repeated use of QoL-questionnaires can detect prodromal periods of an AC.
methods110 patients with AD were asked to complete the disease specific-QoL questionnaire AddiQoL and a short questionnaire about adverse events once monthly over a period of ten months. AC was defined if at least two of the following symptoms were reported: (a) hypotension, (b) nausea or vomiting, (c) severe fatigue, (d) documented hyponatremia, hyperkalemia, or hypoglycemia, and subsequent parenteral glucocorticoid administration was carried out.
resultsPrevalence of AC was 10.9/100 patient years. AddiQoL scores in patients with AC showed a trend (p = 0,08) to a wider fluctuation over time. Subjective precrises not meeting the criteria for AC were reported by 31 patients who had significantly lower AddiQoL scores (p = 0,018).
conclusionsThese are the first data showing the course of QoL during a period of ten months in patients with AD. Incidence of AC exceeds previous data. Our data show, that subjective precrises in AD associate with lower QoL. AC, as well as precrises affect intraindividual AddiQol-scores over time with a trend to a stronger fluctuation. Longitudinal AddiQol scores and self-reporting of precrises via patient diaries are additional clinical tools to identify higher risk for critical events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.