Evidence map›Paper›PMID 29387985›Full record

ArticleMedical oncology (Northwood, London, England)2018

Genetic polymorphism of calcium-sensing receptor in women with breast cancer.

Larysse Maira Campos-Verdes, João Paulo da Silva-Sampaio, Danylo Rafhael Costa-Silva, Victor Alves de Oliveira, Airton Mendes Conde Junior, Vladimir Costa Silva, Airlane Pereira Alencar, Viriato Campelo, Pedro Vitor Lopes-Costa, Luiz Henrique Gebrim and 1 more

Open access · greenAbstract read
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In one paragraph

Article in Medical oncology (Northwood, London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Larysse Maira Campos-VerdesPostgaduate Program of Health and Sciences, Federal University of Piaui, Teresina, 64049-550, Brazil.
João Paulo da Silva-SampaioPostgaduate Program of Health and Sciences, Federal University of Piaui, Teresina, 64049-550, Brazil.
Danylo Rafhael Costa-SilvaPostgraduate Program of the Northeast Network of Biotechnology (RENORBIO), Federal University of Piauí, Teresina, 64049-550, Brazil.
Victor Alves de OliveiraPostgaduate Program of Health and Sciences, Federal University of Piaui, Teresina, 64049-550, Brazil.
Airton Mendes Conde JuniorPostgaduate Program of Health and Sciences, Federal University of Piaui, Teresina, 64049-550, Brazil.
Vladimir Costa SilvaDepartment of Molecular Biology, Natan Portella Hospital, Federal University of Piaui, Teresina, 64001-450, Brazil.
Airlane Pereira AlencarDepartment of Statistics, State University of São Paulo, São Paulo, 03178-200, Brazil.
Viriato CampeloPostgaduate Program of Health and Sciences, Federal University of Piaui, Teresina, 64049-550, Brazil.
Pedro Vitor Lopes-CostaPostgaduate Program of Health and Sciences, Federal University of Piaui, Teresina, 64049-550, Brazil.
Luiz Henrique GebrimDepartment of Mastology, Federal University of Sao Paulo, Sao Paulo, 04023-900, Brazil.
Benedito Borges da SilvaPostgaduate Program of Health and Sciences, Federal University of Piaui, Teresina, 64049-550, Brazil. beneditoborges@globo.com.
Universidade Federal do Piauí · BRUniversidade de São Paulo · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is a disease of unknown etiology, whose major risk factors are genetic alterations. Polymorphism of the calcium-sensing receptor (CaSR) has been a focus of some recent studies, due to a probable association with breast cancer risk and tumor aggressiveness. A relationship between polymorphic rs17251221 variant of the CaSR gene, and allele G (considered a gain-of-function mutation) and breast cancer risk has been stressed, despite the paucity of studies found in the literature. The present study involved 137 women (69 women with breast cancer-case; and 68 controls without breast cancer) who had 3 ml of peripheral blood drawn for DNA study. Genomic DNA was extracted from leukocytes by genotyping technique with real-time polymerase chain reaction. The AG genotype (rs17251221) was present in 13 women (18.84%) from the case group and in 8 (11.76%) women from the control group (p = 0.3434), while the GG genotype (rs17251221) did not occur in any group. In contrast, no statistically significant difference was observed between the AG genotype of variant rs17251221 in premenopausal case and control women (p = 0.71). There was also no statistically significant difference between postmenopausal case and control patients (p = 0.6851). In the current study, CaSR gene polymorphism of SNP variant rs17251221 did not show any statistically significant association with breast cancer, in both premenopausal and postmenopausal women.

Indexed as

Polymorphism, Single NucleotideBiomarkers, TumorBreast NeoplasmsCase-Control StudiesCross-Sectional StudiesFemaleFollow-Up StudiesGenetic Predisposition to DiseaseHumansMiddle AgedPrognosisReceptors, Calcium-SensingBiomarkers, TumorCASR protein, humanReceptors, Calcium-SensingBreast cancerCalciumCaSR polymorphismMenopausal statusqPCR

Identifiers

PMID29387985
OpenAlexW2786036724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.