ArticleImmunogenetics2018
Signatures of historical selection on MHC reveal different selection patterns in the moor frog (Rana arvalis).
Article in Immunogenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Immunological surveillance against cancer across mammals.Nature communications · 2025Article
- Selection of geographical populations suitable for artificial breeding of the Northeast China Brown Frog (Rana dybowskii).Die Naturwissenschaften · 2025Article
- Metamorphosis Reverses the Behavioral Phenotype inEcology and evolution · 2025Article
- MHC Diversity Across Time and Space.Ecology and evolution · 2025Review
- The Amphibian Major Histocompatibility Complex-A Review and Future Outlook.Journal of molecular evolution · 2025Review
- Batrachochytrium dendrobatidis strain affects transcriptomic response in liver but not skin in latitudinal populations of the common toad (Bufo bufo).Scientific reports · 2024Article
- Evidence for selective sweeps in the MHC gene repertoire of various cattle breeds.Animal biotechnology · 2023Article
- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
- Comparative Analysis ofVeterinary sciences · 2021Article
- Hybridization with mountain hares increases the functional allelic repertoire in brown hares.Scientific reports · 2021Article
- Population demographic history and adaptability of the vulnerable Lolokou Sucker Frog.Genetica · 2020Article
- Latitudinal diversity gradient and cetaceans from the perspective of MHC genes.Immunogenetics · 2020Article
- Antimicrobial peptide and sequence variation along a latitudinal gradient in two anurans.BMC genetics · 2020Article
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4 authors.
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Abstract
MHC genes are key components in disease resistance and an excellent system for studying selection acting on genetic variation in natural populations. Current patterns of variation in MHC genes are likely to be influenced by past and ongoing selection as well as demographic fluctuations in population size such as those imposed by post-glacial recolonization processes. Here, we investigated signatures of historical selection and demography on an MHC class II gene in 12 moor frog populations along a 1700-km latitudinal gradient. Sequences were obtained from 207 individuals and consecutively assigned into two different clusters (northern and southern clusters, respectively) in concordance with a previously described dual post-glacial colonization route. Selection analyses comparing the relative rates of non-synonymous to synonymous substitutions (dN/dS) suggested evidence of different selection patterns in the northern and the southern clusters, with divergent selection prevailing in the south but uniform positive selection predominating in the north. Also, models of codon evolution revealed considerable differences in the strength of selection: The southern cluster appeared to be under strong selection while the northern cluster showed moderate signs of selection. Our results indicate that the MHC alleles in the north diverged from southern MHC alleles as a result of differential selection patterns.
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