Evidence map›Paper›PMID 29387910›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018

Bone density and microarchitecture in hepatitis C and HIV-coinfected postmenopausal minority women.

M T Yin, A RoyChoudhury, K Nishiyama, T Lang, J Shah, S Olender, D C Ferris, C Zeana, A Sharma, B Zingman and 3 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

M T YinColumbia University Medical Center, 630 w168th street, New York, NY, 10032, USA. Mty4@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-9346-9056
A RoyChoudhuryCornell University Joan and Sanford I Weill Medical College, New York, NY, USA.
K NishiyamaColumbia University Medical Center, 630 w168th street, New York, NY, 10032, USA.
T LangUniversity of California San Francisco, San Francisco, CA, USA.
J ShahColumbia University Medical Center, 630 w168th street, New York, NY, 10032, USA.
S OlenderColumbia University Medical Center, 630 w168th street, New York, NY, 10032, USA.
D C FerrisBronx-Lebanon Hospital Center, Bronx, NY, USA.
C ZeanaBronx-Lebanon Hospital Center, Bronx, NY, USA.
A SharmaMontefiore, Yeshiva University Albert Einstein College of Medicine, Bronx, NY, USA.
B ZingmanMontefiore, Yeshiva University Albert Einstein College of Medicine, Bronx, NY, USA.
M BucovskyColumbia University Medical Center, 630 w168th street, New York, NY, 10032, USA.
I ColonColumbia University Medical Center, 630 w168th street, New York, NY, 10032, USA.
E ShaneColumbia University Medical Center, 630 w168th street, New York, NY, 10032, USA.
Columbia University Irving Medical Center · USAlbert Einstein College of Medicine · USBronx-Lebanon Hospital Center · USCornell University · USUniversity of California, San Francisco · US

Funding

Office of Extramural Research, National Institutes of Health AI059884Office of Extramural Research, National Institutes of Health AI1065200Office of Extramural Research, National Institutes of Health UL1TR001873
6 · The paper itself

Abstract

We found that HIV+/HCV+ women had 7-8% lower areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA) at the spine, hip, and radius (p < 0.01) and 5-7% lower volumetric BMD (vBMD) by central quantitative computed tomography (cQCT) at the spine and hip (p < 0.05). These data suggest that true deficits in vBMD may contribute to bone fragility and excess fractures reported in HIV+/HCV+ women.

introductionaBMD by DXA is lower in persons coinfected with HIV and HCV (HIV+/HCV+) than with HIV monoinfection (HIV+). However, weight is often also lower with HCV infection, and measurement of aBMD by DXA can be confounded by adiposity; we aimed to determine whether true vBMD is also lower in HIV+/HCV+ coinfection.

methodsWe measured aBMD of the lumbar spine (LS), total hip (TH), femoral neck (FN), and ultradistal radius (UDR) by DXA and vBMD of the spine and hip by cQCT and of the distal radius and tibia by high-resolution peripheral QCT (HRpQCT) in 37 HIV+/HCV+ and 119 HIV+ postmenopausal women. Groups were compared using Student's t tests with covariate adjustment by multiple regression analysis.

resultsHIV+/HCV+ and HIV+ women were of similar age and race/ethnicity. HIV+/HCV+ women had lower body mass index (BMI) and trunk fat and were more likely to smoke and less likely to have a history of AIDS. In HIV+/HCV+ women, aBMD by DXA was 7-8% lower at the LS, TH, and UDR (p < 0.01). Similarly, vBMD by cQCT was 5-7% lower at the LS and TH (p < 0.05). Between-group differences in LS aBMD and vBMD remained significant after adjustment for BMI, smoking, and AIDS history. Tibial total vBMD by HRpQCT was 10% lower in HIV+/HCV+ women.

conclusionHIV+/HCV+ postmenopausal women had significantly lower spine aBMD and vBMD. These deficits in vBMD may contribute to bone fragility and excess fractures reported in HIV+/HCV+ women.

Indexed as

Absorptiometry, PhotonBlack or African AmericanBone DensityCoinfectionFemaleHepatitis CHip JointHispanic or LatinoHIV InfectionsHumansLumbar VertebraeMiddle AgedMinority GroupsOsteoporosis, PostmenopausalRadiusTibiaBone densityHepatitis C infectionHIV infectionQuantitative CT

Identifiers

PMID29387910
OpenAlexW2786158217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.