ReviewExperimental brain research2018
Hippocampal area CA2: an emerging modulatory gateway in the hippocampal circuit.
Review in Experimental brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Hippocampal CA2 to CA1: A metaplastic switch for memory encoding.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Synapses tagged, memories kept: synaptic tagging and capture hypothesis in brain health and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Immunohistochemical field parcellation of the human hippocampus along its antero-posterior axis.Brain structure & function · 2024Article
- Autoimmune processes in neurological patients are much more common than presently suspected.Journal of neurology · 2023Article
- Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation.Nature communications · 2023Article
- Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress.Hippocampus · 2023Article
- Neuromodulator-dependent synaptic tagging and capture retroactively controls neural coding in spiking neural networks.Scientific reports · 2022Article
- A dorsal CA2 to ventral CA1 circuit contributes to oxytocinergic modulation of long-term social recognition memory.Journal of biomedical science · 2022Article
- A circuit from dorsal hippocampal CA3 to parvafox nucleus mediates chronic social defeat stress-induced deficits in preference for social novelty.Science advances · 2022Article
- Hypoxia/Ischemia-Induced Rod Microglia Phenotype in CA1 Hippocampal Slices.International journal of molecular sciences · 2022Article
- Serotonin facilitates late-associative plasticity via synaptic tagging/cross-tagging and capture at hippocampal CA2 synapses in male rats.Oxford open neuroscience · 2022Article
- Interpersonal Family Dynamics Relate to Hippocampal CA Subfield Structure.Frontiers in neuroscience · 2022Article
- Metaplastic Reinforcement of Long-Term Potentiation in Hippocampal Area CA2 by Cholinergic Receptor Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Plasticity in the Hippocampus, Neurogenesis and Drugs of Abuse.Brain sciences · 2021Review
- Newborn mice form lasting CA2-dependent memories of their mothers.Cell reports · 2021Article
- Linking Social Cognition to Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Article
- Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield.Frontiers in molecular neuroscience · 2020Article
- Adaptation to single housing is dynamic: Changes in hormone levels, gene expression, signaling in the brain, and anxiety-like behavior in adult male C57Bl/6J mice.Hormones and behavior · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus is a critical brain region for the formation of declarative memories. While social memory had long been attributed to be a function of the hippocampus, it is only of late that the area CA2 of the hippocampus was demarcated as essential for social memory formation. In addition to this distinct role, CA2 possesses unique molecular, structural and physiological characteristics compared to the other CA regions-CA1 and CA3, and the dentate gyrus (DG). CA2 pyramidal neurons are positioned at a location between CA1 and CA3, receiving inputs from CA3 and DG, in addition to forming a powerful disynaptic circuit with direct input from the entorhinal cortical layer II neurons. CA2 also receives direct inputs from the hypothalamic regions and displays a unique expression pattern for receptors for neuromodulators. The location, inputs, and molecular signatures of the area CA2 point to the possibility that CA2 serves as a modulatory gateway that processes information from the entorhinal cortex and CA3, before relaying them onto CA1, the major output of the hippocampus. This review discusses recent findings regarding plasticity and neuromodulation in the CA2 region of the hippocampus, and how this may have the potential to influence plasticity in connecting circuits, and thereby memory and behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.