ArticleLab on a chip2018
Microfluidic detection of movements of Escherichia coli for rapid antibiotic susceptibility testing.
Article in Lab on a chip, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- A rapid method of evaluating cytotoxic drug efficacy using sub-cellular fluctuation imaging.Scientific reports · 2025Article
- High-throughput chip-calorimeter using a BiMicrosystems & nanoengineering · 2025Article
- Droplet-Based Microfluidics in Single-Bacterium Analysis: Advancements in Cultivation, Detection, and Application.Biosensors · 2025Review
- Microfluidic systems and ultrasonics for emulsion-based biopolymers: A comprehensive review of techniques, challenges, and future directions.Ultrasonics sonochemistry · 2025Review
- Microfluidic technologies for advanced antimicrobial susceptibility testing.Biomicrofluidics · 2024Review
- Measuring single-cell susceptibility to antibiotics within monoclonal bacterial populations.PloS one · 2024Article
- Accurate Prediction of Antimicrobial Susceptibility for Point-of-Care Testing of Urine in Less than 90 Minutes via iPRISM Cassettes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Single-cell pathogen diagnostics for combating antibiotic resistance.Nature reviews. Methods primers · 2023Article
- Measurement of the low-frequency charge noise of bacteria.Physical review. E · 2022Article
- Single-Cell Motility Rapidly Quantifying Heteroresistance in Populations ofSmall science · 2022Article
- Color-Coded Droplets and Microscopic Image Analysis for Multiplexed Antibiotic Susceptibility Testing.Biosensors · 2021Article
- Microscopic Analysis of Bacterial Inoculum Effect Using Micropatterned Biochip.Antibiotics (Basel, Switzerland) · 2021Article
- Recurrent Urinary Tract Infections: Unraveling the Complicated Environment of Uncomplicated rUTIs.Frontiers in cellular and infection microbiology · 2021Review
- Advances in automated techniques to identifyAsian biomedicine : research, reviews and news · 2020Review
- All-electrical monitoring of bacterial antibiotic susceptibility in a microfluidic device.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Identification and Antimicrobial Susceptibility Testing ofApplied and environmental microbiology · 2020Article
- Cross-Flow Filtration ofMicromachines · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Various nanomechanical movements of bacteria provide a signature of bacterial viability. Most notably, bacterial movements have been observed to subside rapidly and dramatically when the bacteria are exposed to effective antibiotics. Thus, monitoring bacterial movements, if performed with high fidelity, could offer a path to various clinical microbiological applications, including antibiotic susceptibility tests. Here, we introduce a robust and ultrasensitive electrical transduction technique for detecting the nanomechanical movements of bacteria. The technique is based on measuring the electrical fluctuations in a microfluidic channel, which the bacteria populate. The swimming of planktonic bacteria and the random oscillations of surface-immobilized bacteria both cause small but detectable electrical fluctuations. We show that this technique provides enough sensitivity to detect even the slightest movements of a single cell; we also demonstrate an antibiotic susceptibility test in a biological matrix. Given that it lends itself to smooth integration with other microfluidic methods and devices, the technique can be developed into a functional antibiotic susceptibility test, in particular, for urinary tract infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.