ArticleBiochemistry and biophysics reports2018
The fabrication of magnetic particle-based chemiluminescence immunoassay for human epididymis protein-4 detection in ovarian cancer.
Article in Biochemistry and biophysics reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- Development of plate-type and tubular chemiluminescence immunoassay against African swine fever virus p72.Applied microbiology and biotechnology · 2024Article
- Optical Detection of Cancer Cells Using Lab-on-a-Chip.Biosensors · 2023Review
- Detection of Carbohydrate Antigen 50 Based on a Novel Miniaturized Chemiluminescence Analyzer Enables Large-Scale Cancer Early Screening in Grassroots Community.Frontiers in bioengineering and biotechnology · 2022Article
- A point-of-care chemiluminescence immunoassay for pepsinogen I enables large-scale community health screening.Analytical and bioanalytical chemistry · 2021Article
- An SPRi Biosensor for Determination of the Ovarian Cancer Marker HE4 in Human Plasma.Sensors (Basel, Switzerland) · 2021Article
- Methods to Study Posttranslational Modification Patterns in Cytotoxic T-Cells and Cancer.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Magnetic Particles for Advanced Molecular Diagnosis.Materials (Basel, Switzerland) · 2019Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The magnetic particles have a significant influence on the immunoassay detection and cancer therapy. Herein, the chemiluminescence immunoassay combined with the magnetic particles (MPCLIA) was presented for the clinical determination and analysis of human epididymis protein 4 (HE4) in the human serum. Under the optimized experiment conditions, the secure MPCLIA method can detect HE4 in the broader range of 0-1000 pmol/L, with a lower detection limit of 1.35 pmol/L. The satisfactory recovery rate of the method in the serum ranged from 83.62% to 105.10%, which was well within the requirement of clinical analysis. Moreover, the results showed the good correlation with enzyme-linked immunosorbent assay (ELISA), with the correlation coefficient of 0.9589. This proposed method has been successfully applied to the clinical determination of HE4 in the human serum.
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