ArticleeNeuro
Opposing and Complementary Topographic Connectivity Gradients Revealed by Quantitative Analysis of Canonical and Noncanonical Hippocampal CA1 Inputs.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Encoding Patterned Spatial Behavior in the Subiculum.Hippocampus · 2026Review
- Topographic CA1 input shapes subicular spatial coding.bioRxiv : the preprint server for biology · 2026Article
- Article
- Non-Canonical Subiculum Circuit Organization and Function.Hippocampus · 2026Review
- Neural circuit mechanisms of epilepsy: Maintenance of homeostasis at the cellular, synaptic, and neurotransmitter levels.Neural regeneration research · 2026Article
- Lateral Thinking: Exploring the Lateral Entorhinal Cortex Projections to the Hippocampus in the Rodent Brain.The Journal of comparative neurology · 2025Review
- Object-translocation induces event coding in the rat hippocampus.Communications biology · 2025Article
- Hippocampal CA3 inhibitory neurons receive extensive noncanonical synaptic inputs from CA1 and subicular complex.The Journal of comparative neurology · 2023Article
- Cell-specific switch for epileptiform activity: critical role of interneurons in the mouse subicular network.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Optogenetics reveals paradoxical network stabilizations in hippocampal CA1 and CA3.Current biology : CB · 2023Article
- Whole-brain input mapping of the lateral versus medial anterodorsal bed nucleus of the stria terminalis in the mouse.Neurobiology of stress · 2023Article
- Noncanonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway.PLoS biology · 2021Article
- Content-specific vulnerability of recent episodic memories in Alzheimer's disease.Neuropsychologia · 2021Article
- Functional differentiation in the transverse plane of the hippocampus: An update on activity segregation within the DG and CA3 subfields.Brain research bulletin · 2021Review
- Subiculum as a generator of sharp wave-ripples in the rodent hippocampus.Cell reports · 2021Article
- Enhancing adult neurogenesis promotes contextual fear memory discrimination and activation of hippocampal-dorsolateral septal circuits.Behavioural brain research · 2021Article
- Transsynaptic Long-Term Potentiation in the Hippocampus of Behaving Mice.Frontiers in synaptic neuroscience · 2021Article
- Neuronal vector coding in spatial cognition.Nature reviews. Neuroscience · 2020Review
- CA1-projecting subiculum neurons facilitate object-place learning.Nature neuroscience · 2019Article
- New viral-genetic mapping uncovers an enrichment of corticotropin-releasing hormone-expressing neuronal inputs to the nucleus accumbens from stress-related brain regions.The Journal of comparative neurology · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Physiological studies suggest spatial representation gradients along the CA1 proximodistal axis. To determine the underlying anatomical basis, we quantitatively mapped canonical and noncanonical inputs to excitatory neurons in dorsal hippocampal CA1 along the proximal-distal axis in mice of both sexes using monosynaptic rabies tracing. Our quantitative analyses show comparable strength of subiculum complex and entorhinal cortex (EC) inputs to CA1, significant inputs from presubiculum and parasubiculum to CA1, and a threefold stronger input to proximal versus distal CA1 from CA3. Noncanonical subicular complex inputs exhibit opposing topographic connectivity gradients whereby the subiculum-CA1 input strength systematically increases but the presubiculum-CA1 input strength decreases along the proximal-distal axis. The subiculum input strength cotracks that of the lateral EC, known to be less spatially selective than the medial EC. The functional significance of this organization is verified physiologically for subiculum-to-CA1 inputs. These results reveal a novel anatomical framework by which to determine the circuit bases for CA1 representations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.