Evidence map›Paper›PMID 29387677›Full record

ArticleAdvanced biomedical research2017

The Effects of Hydroalcoholic Extract of

Roghayeh Pakdel, Hossien Hadjzadeh, Majid Mohammad Sadegh, Mahmoud Hosseini, Bahman Emami, Mousa-Al-Reza Hadjzadeh

Open access · goldAbstract read
In one paragraph

Article in Advanced biomedical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Effect ofNarra J · 2025
    Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Roghayeh PakdelDepartment of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Hossien HadjzadehDepartment of Clinical Science, Veterinary Medicine Faculty, Islamic Azad University, Garmsar Branch, Garmsar, Iran.
Majid Mohammad SadeghDepartment of Clinical Science, Veterinary Medicine Faculty, Islamic Azad University, Garmsar Branch, Garmsar, Iran.
Mahmoud HosseiniDepartment of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Bahman EmamiDepartment of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mousa-Al-Reza HadjzadehDepartment of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Islamic Azad University of Garmsar · IRMashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was investigation of the effects of MATERIALS AND

methodsHypothyroidism was induced by propylthiouracil (PTU) 0.03% in drinking water. Female rats were divided into seven groups: control, PTU, PTU-NS (100, 200, and 400 mg/kg), and NS (100 and 400 mg/kg). All treatments were done 20 days before mating and during pregnancy. The weight of rat dams and progenies, number of progenies and serum T4, estradiol and prolactin (PRL) levels in rat dams were measured for all groups.

resultsSerum T4 in all PTU-NS groups before mating was significantly increased versus PTU group. Body weight of rat dams before mating in all groups of PTU-NS was increased versus PTU group by

conclusionThese results demonstrated that feeding of rat dams with NS extract before mating has positive protective effects on progenies. These effects may be due to antioxidant properties of NS in reducing oxidative stress and thyroid damages induced by PTU.

Indexed as

HypothyroidNigella sativaprogenypropylthiouracilrat dams

Identifiers

PMID29387677
PMCPMC5767798
OpenAlexW2777095315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.