ArticleAvicenna journal of phytomedicine
Protective effect of crocin against d-galactose-induced aging in mice.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Zingerone mitigates cognitive and motor impairments in a D-galactose-induced brain aging model: Role of oxidative stress and neuroinflammation.Molecular biology reports · 2026Article
- A High Dose of Short-term Intraperitoneal D-galactose-induced Aging Process in Male Rats.Annals of African medicine · 2026Article
- Low serum dehydroepiandrosterone sulfate is related to diabetic retinopathy in males with type 2 diabetes mellitus.Journal of translational medicine · 2026Article
- Antioxidant and neuromodulatory effect of gallic acid prevents anxiety-like symptoms of omeprazole.RSC advances · 2026Article
- Targeting Cardiotoxicity Induced by Environmental Toxins: The Role of Natural Products.Cardiovascular toxicology · 2025Review
- Rutin-Whey Protein Nanoparticles Inhibit D-Galactose-Induced Skeletal Muscle Dysfunction by Modulating Gut Microbiota and Metabolic Pathways.Nutrients · 2025Article
- Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Radioprotective Effect of Resveratrol, Crocin, and Their Combination on Cytogenetic Alterations in Human Lymphocytes.Journal of biomedical physics & engineering · 2024Article
- Aging Parameters of the Accelerated Aging Procedure through D-Galactose Induction.Acta medica Philippina · 2024Article
- Review
- Article
- Crocin's effect on phenotype switching of J774A.1 macrophages depends on their polarization state during exposure.Iranian journal of basic medical sciences · 2023Article
- Impact of caffeic acid on the testicular damages in D-galactose-induced aging model in mice.Iranian journal of basic medical sciences · 2022Article
- Oxidation Stress as a Mechanism of Aging in Human Erythrocytes: Protective Effect of Quercetin.International journal of molecular sciences · 2022Article
- D-galactose induced dysfunction in mice hippocampus and the possible antioxidant and neuromodulatory effects of selenium.Environmental science and pollution research international · 2022Article
- In search of elixir: Pharmacological agents against stem cell senescence.Iranian journal of basic medical sciences · 2021Review
- Protective effects of ginseng stem-leaf saponins on D-galactose-induced reproductive injury in male mice.Aging · 2021Article
- Recent Progress in Environmental Toxins-Induced Cardiotoxicity and Protective Potential of Natural Products.Frontiers in pharmacology · 2021Review
- Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells.Iranian journal of basic medical sciences · 2020Article
- Looking for immortality: Review of phytotherapy for stem cell senescence.Iranian journal of basic medical sciences · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAging is a multifactorial phenomenon, which attribute to different diseases and abnormalities in living systems. Oxidative stress, which is an important factor in aging, exacerbates this process via different mechanisms. Crocin (CR), one of the active components of saffron showed strong antioxidant effects. In the present study, anti-aging property of crocin was investigated in mice. MATERIALS AND
methodsThe model of aging was induced using administration of d-galactose (500 mg/kg, s. c.) for 42 days. Animals were treated with crocin (10, 20, 40 mg/kg, i.p.) during treatment with d-galactose. At the end of treatment, levels of malondialdehyde (MDA) as a lipid peroxidation marker and glutathione content (GSH) in the liver and brain were measured. Also, biochemical factors including liver enzymes (ALT and AST), male sex hormones including testosterone and dehydroepiandrosterone-sulfate (DHEA-SO
resultsAdministration of d-galactose led to induction of lipid peroxidation in liver and brain tissues, as well as elevation of AST, ALT, and pro-inflammatory cytokines and reduction of male sex hormones levels in serum. Interestingly, treatment of animals with crocin (10, 20 and 40 mg/kg) diminished lipid peroxidation in the liver and brain tissues while elevated GSH content. Also, a decline in serum levels of TNF-α and IL-6 and an elevation of male sex hormones were observed following treatment with crocin.
conclusionAdministration of crocin reduced d-galactose-induced aging in mice through inhibition of oxidative stress, reduction of inflammation and elevation of sex hormones.
Indexed as
Identifiers
29387570PMC5787993W2764298290What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.