Evidence map›Paper›PMID 29387527›Full record

ArticleNeuroImage. Clinical2018

High brain serotonin levels in migraine between attacks: A 5-HT

Marie Deen, Hanne D Hansen, Anders Hougaard, Martin Nørgaard, Hans Eiberg, Szabolcs Lehel, Messoud Ashina, Gitte M Knudsen

Open access · goldAbstract read
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Personality profile and depression in migraine: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Revisiting Migraine Pathophysiology: from Neurons To Immune Cells Through Lens of Immune Regulatory Pathways.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Migraine and Its Treatment from the Medicinal Chemistry Perspective.ACS pharmacology & translational science · 2024
    Review
  14. Review
  15. Review
  16. The Roles of Serotonin in Neuropsychiatric Disorders.Cellular and molecular neurobiology · 2022
    Review
  17. Radiotracers for the Central Serotoninergic System.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  18. Review
  19. False positive rates in positron emission tomography (PET) voxelwise analyses.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  20. Migraine and Mood in Children.Behavioral sciences (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marie DeenDanish Headache Center, Department of Neurology, Rigshospitalet, DK-2600 Glostrup, Denmark; Neurobiology Research Unit and NeuroPharm, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark; Center for Experimental Medicine Neuropharmacology, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark.
Hanne D HansenNeurobiology Research Unit and NeuroPharm, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark; Center for Experimental Medicine Neuropharmacology, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark.
Anders HougaardDanish Headache Center, Department of Neurology, Rigshospitalet, DK-2600 Glostrup, Denmark; Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark.
Martin NørgaardNeurobiology Research Unit and NeuroPharm, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Center for Experimental Medicine Neuropharmacology, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark.
Hans EibergDepartment of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Szabolcs LehelPET- and Cyclotron Unit, Rigshospitalet, DK-2100 Copenhagen, Denmark.
Messoud AshinaDanish Headache Center, Department of Neurology, Rigshospitalet, DK-2600 Glostrup, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark.
Gitte M KnudsenNeurobiology Research Unit and NeuroPharm, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Center for Experimental Medicine Neuropharmacology, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark. Electronic address: gitte@nru.dk.
University of Copenhagen · DKRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine has been hypothesized to be a syndrome of chronic low serotonin (5-HT) levels, but investigations of brain 5-HT levels have given equivocal results. Here, we used positron emission tomography (PET) imaging of the 5-HT

Indexed as

AdolescentAdultBrainFemaleHumansMaleMigraine DisordersNeuroimagingPositron-Emission TomographyReceptors, Serotonin, 5-HT4SerotoninYoung AdultReceptors, Serotonin, 5-HT4SerotoninBrainHeadacheNeuroimagingPainSerotonergic mechanisms

Identifiers

PMID29387527
PMCPMC5790018
OpenAlexW2790632305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.