Evidence map›Paper›PMID 29387524›Full record

ArticleNeuroImage. Clinical2018

Evidence of progressive tissue loss in the core of chronic MS lesions: A longitudinal DTI study.

Alexander Klistorner, Chenyu Wang, Con Yiannikas, John Parratt, Michael Dwyer, Joshua Barton, Stuart L Graham, Yuyi You, Sidong Liu, Michael H Barnett

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Ibudilast reduces slowly enlarging lesions in progressive multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024
    Trial
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  18. Review
  19. In vivo imaging of chronic active lesions in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander KlistornerSave Sight Institute, Sydney Medical School, University of Sydney, Sydney, Australia; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia; Sydney Neuroimaging Analysis Centre, Sydney, NSW, Australia. Electronic address: sasha.klistorner@sydney.edu.au.
Chenyu WangSydney Neuroimaging Analysis Centre, Sydney, NSW, Australia; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
Con YiannikasRoyal North Shore Hospital, Sydney, NSW, Australia.
John ParrattRoyal North Shore Hospital, Sydney, NSW, Australia.
Michael DwyerBuffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA.
Joshua BartonBrain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
Stuart L GrahamFaculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.
Yuyi YouSave Sight Institute, Sydney Medical School, University of Sydney, Sydney, Australia; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.
Sidong LiuSave Sight Institute, Sydney Medical School, University of Sydney, Sydney, Australia; Sydney Neuroimaging Analysis Centre, Sydney, NSW, Australia; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
Michael H BarnettSydney Neuroimaging Analysis Centre, Sydney, NSW, Australia; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Using diffusion tensor imaging (DTI), we examined chronic stable MS lesions, peri-lesional white matter (PLWM) and normal appearing white matter (NAWM) in patients with relapsing-remitting multiple sclerosis (RRMS) for evidence of progressive tissue destruction and evaluated whether diffusivity change is associated with conventional MRI parameters and clinical findings. Method: Pre- and post-gadolinium T1, T2 and DTI images were acquired from 55 consecutive RRMS patients at baseline and 42.3 ± 9.7 months later. Chronic stable T2 lesions of sufficient size were identified in 43 patients (total of 134 lesions). Diffusivity parameters such as axial diffusivity (AD), radial diffusivity (RD), mean diffusivity (MD) and fractional anisotropy (FA) were compared at baseline and follow-up. MRI was also performed in 20 normal subjects of similar age and gender. Results: Within the core of chronic MS lesions the diffusion of water molecules significantly increased over the follow-up period, while in NAWM all diffusivity indices remained stable. Since increase of AD and RD in lesional core was highly concordant, indicating isotropic nature of diffusivity change, and considering potential effect of crossing fibers on directionally-selective indices, only MD, a directionally-independent measure, was used for further analysis. The significant increase of MD in the lesion core during the follow-up period (1.29 ± 0.19 μm Conclusion: The significant increase of isotropic water diffusion in the core of chronic stable MS lesions likely reflects gradual, self-sustained tissue destruction in demyelinated white matter that is more aggressive in males.

Indexed as

Diffusion Tensor ImagingAdultAnalysis of VarianceAtrophyBrainBrain MappingDisease ProgressionFemaleHumansImage Processing, Computer-AssistedLateral VentriclesLongitudinal StudiesMaleMiddle AgedMultiple SclerosisSex FactorsChronic demyelinationDiffusionLesionsMultiple sclerosis

Identifiers

PMID29387524
PMCPMC5772506

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.