ArticleBiomedical reports2018
Low levels of linoleic acid and α-linolenic acid and high levels of arachidonic acid in plasma phospholipids are associated with hypertension.
Article in Biomedical reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Replacing Saturated Fat With Walnuts or Vegetable Oils Improves Central Blood Pressure and Serum Lipids in Adults at Risk for Cardiovascular Disease: A Randomized Controlled-Feeding Trial.Journal of the American Heart Association · 2019Trial
- Trial
- Association Between Circulating Fatty Acids and Blood Pressure: A Review.Current nutrition reports · 2025Review
- Metabolomics of the effects of Yishenjiangya granules in older adults with hypertension.Frontiers in pharmacology · 2025Article
- Research on the mechanism of the anti-myocardial infarction effect of the Qiliqiangxin capsule on heart failure rats via nontargeted metabolomics and lipidomics.BMC cardiovascular disorders · 2024Article
- Comparative Transcriptomic and Lipidomic Analysis of Fatty Acid Accumulation in ThreeJournal of agricultural and food chemistry · 2024Article
- Inflammation Resolution in the Cardiovascular System: Arterial Hypertension, Atherosclerosis, and Ischemic Heart Disease.Antioxidants & redox signaling · 2024Review
- Phytoconstituent Profiles Associated with Relevant Antioxidant Potential and Variable Nutritive Effects of the Olive, Sweet Almond, and Black Mulberry Gemmotherapy Extracts.Antioxidants (Basel, Switzerland) · 2023Article
- Association of dietary fatty acid intake with hypertension in children and adolescents: evidence from the NHANES 2005-2018.Frontiers in pediatrics · 2023Article
- Decompression Mechanism of Radish Seed in Prehypertension Rats through Integration of Transcriptomics and Metabolomics Methods.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- The metabolomics of a protein kinase C delta (PKCδ) knock-out mouse model.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Comprehensive biomarker profiling of hypertension in 36 985 Finnish individuals.Journal of hypertension · 2022Article
- The Short Overview on the Relevance of Fatty Acids for Human Cardiovascular Disorders.Biomolecules · 2020Review
- Polyunsaturated fatty acids produce a range of activators for heterogeneous IKs channel dysfunction.The Journal of general physiology · 2020Article
- α-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux.Cell death & disease · 2020Article
- Importance of Flaxseed and its Components in the Management of Hypertension.The International journal of angiology : official publication of the International College of Angiology, Inc · 2019Review
- Study on the Antihypertensive Mechanism ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary fat is an important determinant in the development and progression of high blood pressure (BP), a major risk factor for cardiovascular diseases and mortality. The aim of the present study was to determine the association between plasma phospholipid fatty acids and hypertension in Japanese men. The plasma level of linoleic acid (LA) in the subjects with hypertension (systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg) was identified to be significantly higher than that in the healthy controls. Following adjustment for age, body mass index, physical activity, smoking status, alcohol consumption, salt intake, and serum levels of glucose and hemoglobin A1c, higher plasma levels of LA and α-linolenic acid (ALA), and lower levels of arachidonic acid (AA) were significantly associated with a lower prevalence of hypertension. The odds ratio (OR) for the highest quartile (Q4) versus the lowest quartile (Q1) of LA was 0.17 (P=0.003), the OR for Q4 versus Q1 of ALA was 0.26 (P=0.042) and the OR for Q4 versus Q1 of AA was 2.04 (P=0.047). These results indicate that elevated levels of LA and ALA, and reduced levels of AA in the plasma prevent hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.