Evidence map›Paper›PMID 29387172›Full record

ArticleBiotechnology for biofuels2018

Engineering

Xochitl Niehus, Anne-Marie Crutz-Le Coq, Georgina Sandoval, Jean-Marc Nicaud, Rodrigo Ledesma-Amaro

Open access · goldAbstract read
In one paragraph

Article in Biotechnology for biofuels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 153 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Effect of Argan Oil on Lipid Production byJournal of microbiology and biotechnology · 2025
    Article
  6. Review
  7. Article
  8. Frontiers in microbiology · 2025
    Review
  9. Tracking trash to treasure:RSC advances · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Conditional protein degradation inFrontiers in bioengineering and biotechnology · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Production of human milk fat substitute by engineered strains ofMetabolic engineering communications · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Xochitl NiehusIndustrial Biotechnology, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco (CIATEJ) A.C., 44270 Guadalajara, Jalisco Mexico.
Anne-Marie Crutz-Le Coq1Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
Georgina SandovalIndustrial Biotechnology, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco (CIATEJ) A.C., 44270 Guadalajara, Jalisco Mexico.
Jean-Marc Nicaud1Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
Rodrigo Ledesma-Amaro1Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.ORCID 0000-0003-2631-5898
Université Paris-Saclay · FRSecretaría de Salud de Jalisco · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

resultsIn this work, we engineered this yeast to efficiently use xylose as a carbon source for the production of lipids by overexpressing native genes. We further increased the lipid content by overexpressing heterologous genes to facilitate the conversion of xylose-derived metabolites into lipid precursors. Finally, we showed that these engineered strains were able to grow and produce lipids in a very high yield (lipid content = 67%, titer = 16.5 g/L, yield = 3.44 g/g sugars, productivity 1.85 g/L/h) on a xylose-rich agave bagasse hydrolysate in spite of toxic compounds.

conclusionsThis work demonstrates the potential of metabolic engineering to reduce the costs of lipid production from inexpensive substrates as source of fuels and chemicals.

Indexed as

Acetyl-CoAMetabolic engineeringMicrobial lipidsSynthetic biologyXylose utilizationYarrowia lipolytica

Identifiers

PMID29387172
PMCPMC5776775
OpenAlexW2784519799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.