ArticleResearch in pharmaceutical sciences2018
Magnesium sulfate protects the heart against carbon monoxide-induced cardiotoxicity in rats.
Article in Research in pharmaceutical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Early-life dentine-based elemental biodynamics and cord blood telomere length.medRxiv : the preprint server for health sciences · 2026Article
- Hesperidin neuroprotective effects against carbon monoxide-induced toxicity in male rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Serum glucose/potassium ratio as an indicator of early and delayed outcomes of acute carbon monoxide poisoning.Toxicology research · 2024Article
- Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer.Cell death discovery · 2024Article
- Carbon monoxide poisoning.Toxicology reports · 2020Review
- Magnesium sulfate ameliorates carbon monoxide‑induced cerebral injury in male rats.Molecular medicine reports · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbon monoxide (CO), a toxic gas produced via incomplete fossil fuel combustion, has several poisonous effects in the heart including induction of necrosis, apoptosis, and electrocardiogram (ECG) changes. Magnesium sulfate (MS) is a drug with cardioprotective effects especially when used after ischemia/reperfusion. In the current study, we aimed to evaluate MS cardioprotective effects following CO poisoning. Animals were exposed to CO 3000 ppm for 1 h and immediately after the exposure period and on the next 4 days (a total of 5 consecutive doses given on a daily basis), MS (75, 150 and 300 mg/kg) was injected intraperitoneally (i.p.) and ECG was recorded focusing on ST-segment, T-wave, and Q-pathologic wave changes. On day 5, animals were sacrificed and their heart was excised for determination of BAX, BCL2 and Akt expression level using western blot analysis and necrosis investigations. The results showed that MS significantly decreased necrosis and BAX/BCL2 ratio (
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