Evidence map›Paper›PMID 29387052›Full record

ArticleFrontiers in immunology2017

Helene B Juel, Helena B Thomaides-Brears, Thomas C Darton, Claire Jones, Elizabeth Jones, Sonu Shrestha, Rebecca Sie, Andrew Eustace, Ushma Galal, Prathiba Kurupati and 5 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01405521 (Understanding Typhoid Disease After Vaccination), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01405521 phase2completednot on this map

Understanding Typhoid Disease After Vaccination: a Single Centre, Randomised, Doubleblind, Placebo Controlled Study to Evaluate M01ZH09 in a Healthy Adult Challenge Model, Using Ty21a Vaccine as a Positive Control.

TypeinterventionalSponsorUniversity of OxfordRan2011 to 2022Enrolled99ConditionsTyphoid Fever, Enteric Fever, TyphoidArmsVaccine placebo (excipients only), Ty21a, M10ZH09 vaccine
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Vaccines for preventing typhoid fever.The Cochrane database of systematic reviews · 2018
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Typhoid fever.Nature reviews. Disease primers · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. AMicroorganisms · 2021
    Article
  16. Antibodies and Protection in SystemicInfection and immunity · 2020
    Review
  17. Deletions inHuman vaccines & immunotherapeutics · 2019
    Article
  18. Human vaccines & immunotherapeutics · 2019
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Helene B JuelOxford Vaccine Group, Department of Paediatrics, University of Oxford, The NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Helena B Thomaides-BrearsOxford Vaccine Group, Department of Paediatrics, University of Oxford, The NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Thomas C DartonOxford Vaccine Group, Department of Paediatrics, University of Oxford, The NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Claire JonesOxford Vaccine Group, Department of Paediatrics, University of Oxford, The NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Elizabeth JonesOxford Vaccine Group, Department of Paediatrics, University of Oxford, The NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Sonu ShresthaOxford Vaccine Group, Department of Paediatrics, University of Oxford, The NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Rebecca SieOxford Vaccine Group, Department of Paediatrics, University of Oxford, The NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Andrew EustaceOxford Vaccine Group, Department of Paediatrics, University of Oxford, The NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Ushma GalalNuffield Department of Primary Care Health Sciences, Clinical Trials Unit, University of Oxford, Oxford, United Kingdom.
Prathiba KurupatiWeatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Tan T VanThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Nga T V ThieuThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Stephen BakerThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Christoph J BlohmkeOxford Vaccine Group, Department of Paediatrics, University of Oxford, The NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Andrew J PollardOxford Vaccine Group, Department of Paediatrics, University of Oxford, The NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
University of Oxford · GBOxford BioMedica (United Kingdom) · GBHospital for Tropical Diseases · VNOxford University Clinical Research Unit · VNStatens Serum Institut · DK

Funding

Wellcome Trust 092661
6 · The paper itself

Abstract

Effective vaccines against

Indexed as

bactericidal activityhuman challenge modelimmune responsesSalmonella enterica Typhityphoid infection

Identifiers

PMID29387052
PMCPMC5776093
OpenAlexW2783759098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.