ReviewFrontiers in physiology2017
Ironing out the Details: Exploring the Role of Iron and Heme in Blood-Sucking Arthropods.
Review in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 74 citations in OpenAlex.
- Regulatory mechanisms of nitrogen homeostasis in insect growth and development.Insect science · 2026Review
- Iron Homeostasis and Reproduction: Unveiling the Microbiome-Gut-Brain Axis Connection in the MosquitoCells · 2026Article
- Influence of hematocrit variation on Cimex lectularius (Hemiptera: Cimicidae) development and reproduction.Journal of medical entomology · 2026Article
- Energetic shifts reflect survival likelihood in Anopheles gambiae.Communications biology · 2025Article
- Assessment of Chlorella vulgaris as a biological control agent against tortoise tick Hyalomma aegyptium (Acari: Ixodidae) in Egypt.Scientific reports · 2025Article
- Genetic and behavioral analyses suggest that larval and adult stages of Lucilia cuprina employ different sensory systems to detect rotten beef.Parasites & vectors · 2025Article
- An insight into the draft genome of the Oriental rat flea, Xenopsylla cheopis, together with its Wolbachia endosymbiont.BMC genomics · 2025Article
- Mechanisms of host exploitation by a microsporidian parasite.Proceedings. Biological sciences · 2025Article
- Deployment and transcriptional evaluation of nitisinone, an FDA-approved drug, to control bed bugs.Pest management science · 2025Article
- Anopheles gambiae phagocytic hemocytes promote Plasmodium falciparum infection by regulating midgut epithelial integrity.Nature communications · 2025Article
- Whole Genome Sequencing Reveals Clade-Specific Genetic Variation in Blacklegged Ticks.Ecology and evolution · 2025Article
- MosAIC: An annotated collection of mosquito-associated bacteria with high-quality genome assemblies.PLoS biology · 2024Article
- Hooked on fish blood: the reliance of a gill parasite on haematophagy.Proceedings. Biological sciences · 2024Article
- Iron Homeostasis in Insects.Annual review of entomology · 2023Review
- Ethanolic Extracts ofGenes · 2022Article
- Phenotypic analyses, protein localization, and bacteriostatic activity of Drosophila melanogaster transferrin-1.Insect biochemistry and molecular biology · 2022Article
- Metal ions in insect reproduction: a crosstalk between reproductive physiology and immunity.Current opinion in insect science · 2022Review
- Acaricidal Potential and Ecotoxicity of Metallic Nano-Pesticides Used against the Major Life Stages ofLife (Basel, Switzerland) · 2022Article
- Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts.Antioxidants (Basel, Switzerland) · 2022Review
- Behavioural regulation of mineral salt intake in honeybees: a self-selection approach.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Heme and iron are essential molecules for many physiological processes and yet have the ability to cause oxidative damage such as lipid peroxidation, protein degradation, and ultimately cell death if not controlled. Blood-sucking arthropods have evolved diverse methods to protect themselves against iron/heme-related damage, as the act of bloodfeeding itself is high risk, high reward process. Protective mechanisms in medically important arthropods include the midgut peritrophic matrix in mosquitoes, heme aggregation into the crystalline structure hemozoin in kissing bugs and hemosomes in ticks. Once heme and iron pass these protective mechanisms they are presumed to enter the midgut epithelial cells via membrane-bound transporters, though relatively few iron or heme transporters have been identified in bloodsucking arthropods. Upon iron entry into midgut epithelial cells, ferritin serves as the universal storage protein and transport for dietary iron in many organisms including arthropods. In addition to its role as a nutrient, heme is also an important signaling molecule in the midgut epithelial cells for many physiological processes including vitellogenesis. This review article will summarize recent advancements in heme/iron uptake, detoxification and exportation in bloodfeeding arthropods. While initial strides have been made at ironing out the role of dietary iron and heme in arthropods, much still remains to be discovered as these molecules may serve as novel targets for the control of many arthropod pests.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.