ArticleNeuropsychiatric disease and treatment2018
Altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fMRI study.
Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- Multi-Spatial Voxel-Scale Modulation of Acupuncture on Abnormal Brain Activity in Migraine Patients Without Aura: A Randomized Study Neuroimaging Trial.Brain and behavior · 2025Trial
- A Cross-Sectional Study of Short-Video Viewing and Young Adult Health: Dose-Response Relationships with Sleep, Dream Anxiety, Ocular Surface, and Quality of Life.Healthcare (Basel, Switzerland) · 2026Article
- Investigating Brain Structure and Functional Alterations in the Transition from Acute to Chronic Neck Pain: A Resting-State fMRI Study.Journal of pain research · 2025Article
- Altered Amplitude of Low-Frequency Fluctuations of rs-fMRI Signal followed by rTMS Analgesic Effects in Non-Specific Chronic Low Back Pain (CLBP) Patients.Journal of biomedical physics & engineering · 2024Article
- Functional connectivity of paired default mode network subregions in patients with eye trauma.International journal of ophthalmology · 2024Article
- Alteration of neural activity and neuroinflammatory factors in the insular cortex of mice with corneal neuropathic pain.Genes, brain, and behavior · 2023Article
- Fractional amplitude of low-frequency fluctuation changes of specific cerebral regions in patients with toothache: A functional magnetic resonance imaging study.Brain and behavior · 2023Article
- Abnormal brain activity in lumbar disc herniation patients with chronic pain is associated with their clinical symptoms.Frontiers in neuroscience · 2023Article
- Frequency-Dependent Alterations in the Amplitude of Low-Frequency Fluctuations in Patients with Acute Pericoronitis: A Resting-State fMRI Study.Journal of pain research · 2023Article
- Amplitude of Low-Frequency Fluctuation to Determine Disturbed Spontaneous Brain-Activity Pattern in Patients with Diabetic Optic Neuropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Differences in Brain Activity Between Dopa-Responsive and -Unresponsive Pain in Parkinson's Disease.Pain and therapy · 2022Article
- Altered spontaneous brain activity patterns in patients with diabetic retinopathy using amplitude of low-frequency fluctuation.World journal of diabetes · 2022Article
- Investigation of changes in the activity and function of dry eye-associated brain regions using the amplitude of low-frequency fluctuations method.Bioscience reports · 2022Article
- Brain Activity Changes in Slow 5 and Slow 4 Frequencies in Patients With Optic Neuritis: A Resting State Functional MRI Study.Frontiers in neurology · 2022Article
- Machine learning analysis reveals abnormal functional network hubs in the primary angle-closure glaucoma patients.Frontiers in human neuroscience · 2022Article
- Abnormal percent amplitude of fluctuation changes in patients with monocular blindness: A resting-state functional magnetic resonance imaging study.Frontiers in psychiatry · 2022Article
- Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study.Scientific reports · 2021Article
- Interhemispheric Functional Connectivity Alterations in Diabetic Optic Neuropathy: A Resting-State Functional Magnetic Resonance Imaging Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Altered spontaneous brain activity patterns in diabetic patients with vitreous hemorrhage using amplitude of low‑frequency fluctuation: A resting‑state fMRI study.Molecular medicine reports · 2020Article
- The predictive potential of altered spontaneous brain activity patterns in diabetic retinopathy and nephropathy.The EPMA journal · 2019Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMany previous studies have reported that pain symptoms can lead to significant brain function and anatomical changes, whereas the intrinsic brain activity changes in acute eye pain (EP) patients remain unknown. Using the amplitude of low-frequency fluctuation (ALFF) method, this study aimed to evaluate the spontaneous brain activity alterations and their relationships with clinical features in acute EP patients. PARTICIPANTS AND
methodsA total of 20 patients with EP (15 males and 5 females) and 20 healthy controls (HCs; 15 males and 5 females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was applied to assess spontaneous brain activity changes. The ALFF values of the EP patients were distinguished from those of the HCs using a receiver operating characteristic curve. Pearson's correlation analysis was used to investigate the relationships between the mean ALFF signal values from many brain regions and the clinical features in EP patients.
resultsCompared with the HCs, acute EP patients had significantly lower ALFF in the left and right precentral/postcentral gyrus and left precuneus. In contrast, acute EP patients showed higher ALFF values in the right and left parahippocampal gyri and left caudate. However, no relationship was observed between the mean ALFF signal values from the different areas and clinical manifestations in the acute EP patients.
conclusionWe demonstrated that acute EP patients showed abnormal intrinsic brain activities in the precentral/postcentral gyrus and limbic system, which might provide useful information for explaining neural mechanisms in EP patients.
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