Evidence map›Paper›PMID 29386650›Full record

ArticleScientific reports2018

Targeted Knockdown of Overexpressed VEGFA or VEGF164 in Müller cells maintains retinal function by triggering different signaling mechanisms.

Silke Becker, Haibo Wang, Aaron B Simmons, Thipparat Suwanmanee, Gregory J Stoddard, Tal Kafri, M Elizabeth Hartnett

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  13. Review
  14. Pathophysiology of Retinopathy of Prematurity.Annual review of vision science · 2023
    Review
  15. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Silke BeckerJohn A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
Haibo WangJohn A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
Aaron B SimmonsJohn A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
Thipparat SuwanmaneeGene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Gregory J StoddardDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Tal KafriGene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
M Elizabeth HartnettJohn A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA. ME.Hartnett@hsc.utah.edu.
University of Utah · USUniversity of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Bryan William Jones · 2005 to 2026
$14.6M
Endothelial Transmigration in Neovascular Age-related Macular DegenerationR01EY017011 · NEI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARTNETT, MARY ELIZABETH RUTH · 2007 to 2025
$7.7M
Mechanisms of Angiogenesis of Retinopathy of PrematurityR01EY015130 · NEI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mary Elizabeth Ruth Hartnett · 2005 to 2026
$7.6M
Nonintegrating Lentiviral Vectors Towards Clinical TrialsR01DK058702 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAFRI, TAL · 2001 to 2019
$5.0M
Lentiviral Vector-Based Gene Therapy and The Host Genetic BackgroundR01HL128119 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAFRI, TAL · 2015 to 2018
$3.0M
Vision Research Training Grant at the University of UtahT32EY024234 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI DAVID KRIZAJ, Monica L Vetter · 2014 to 2026
$2.3M
NCI NIH HHS P30 CA016086NEI NIH HHS P30 EY014800NEI NIH HHS R01 EY015130NEI NIH HHS R01 EY017011NEI NIH HHS T32 EY024234NHLBI NIH HHS R01 HL128119NIDDK NIH HHS R01 DK058702
6 · The paper itself

Abstract

Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown of Müller cell-VEGFA with short-hairpin RNAs to VEGFA or VEGF

Indexed as

Signal TransductionAnimalsAstrocytesBrain-Derived Neurotrophic FactorCells, CulturedErythropoietinGene Knockdown TechniquesGene SilencingGlial Cell Line-Derived Neurotrophic FactorNerve Growth FactorNeurotrophin 3RatsRats, Sprague-DawleyRetinaRetinopathy of PrematurityVascular Endothelial Growth Factor ABrain-Derived Neurotrophic FactorErythropoietinGlial Cell Line-Derived Neurotrophic FactorNerve Growth FactorNeurotrophin 3Vascular Endothelial Growth Factor Avascular endothelial growth factor A, rat

Identifiers

PMID29386650
PMCPMC5792486
OpenAlexW2806786818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.