ArticleNature communications2018
A naturally occurring epiallele associates with leaf senescence and local climate adaptation in Arabidopsis accessions.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Genetic and epigenetic mechanisms underlying cadmium (Cd) stress responses in soybean cultivars.Plant cell reports · 2026Article
- Combined hormonomic, transcriptomic, and metabolomic analyses reveal the role of programmed cell death in bud abscission of Chinese chestnut (Frontiers in plant science · 2026Article
- Nanopore sequencing and multiomics reveal predictable non-coding RNA activation in DNA methylation deficient Arabidopsis thaliana.Communications biology · 2025Article
- Dam-dependent epigenetic memory regulates prophage reintegration in Salmonella.Nucleic acids research · 2025Article
- Article
- Maternal environmental effects and climate-smart seeds: unlocking epigenetic inheritance for crop innovation in the seed industry.The Plant journal : for cell and molecular biology · 2025Article
- Partial redundancy buffers deleterious effects of mutating DNA methyltransferase 1-1 (MET1-1) in polyploid wheat.Journal of experimental botany · 2025Article
- Epiallelic Variation of TILLER ANGLE CONTROL 5 (TAC5) Regulates Tiller Angle by Modulating Gravitropism in Rice.Rice (New York, N.Y.) · 2025Article
- Genetic Foundation of Leaf Senescence: Insights from Natural and Cultivated Plant Diversity.Plants (Basel, Switzerland) · 2024Review
- The OsAGO2-OsNAC300-OsNAP module regulates leaf senescence in rice.Journal of integrative plant biology · 2024Article
- Recent Advances in Studies of Genomic DNA Methylation and Its Involvement in Regulating Drought Stress Response in Crops.Plants (Basel, Switzerland) · 2024Review
- Two adjacent NLR genes conferring quantitative resistance to clubroot disease in Arabidopsis are regulated by a stably inherited epiallelic variation.Plant communications · 2024Article
- Profiling genome-wide methylation in two maples: Fine-scale approaches to detection with nanopore technology.Evolutionary applications · 2024Article
- The Sink-Source Relationship in Cucumber (Plants (Basel, Switzerland) · 2023Article
- Taming transposable elements in livestock and poultry: a review of their roles and applications.Genetics, selection, evolution : GSE · 2023Review
- DDM1-mediated gene body DNA methylation is associated with inducible activation of defense-related genes in Arabidopsis.Genome biology · 2023Article
- Heritable responses to stress in plants.Quantitative plant biology · 2023Review
- Epigenetic control of plant senescence and cell death and its application in crop improvement.Frontiers in plant science · 2023Review
- Canalization of genome-wide transcriptional activity in Arabidopsis thaliana accessions by MET1-dependent CG methylation.Genome biology · 2022Article
- Exploitation of epigenetic variation of crop wild relatives for crop improvement and agrobiodiversity preservation.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic variation has been proposed to facilitate adaptation to changing environments, but evidence that natural epialleles contribute to adaptive evolution has been lacking. Here we identify a retrotransposon, named "NMR19" (naturally occurring DNA methylation variation region 19), whose methylation and genomic location vary among Arabidopsis thaliana accessions. We classify NMR19 as NMR19-4 and NMR19-16 based on its location, and uncover NMR19-4 as an epiallele that controls leaf senescence by regulating the expression of PHEOPHYTIN PHEOPHORBIDE HYDROLASE (PPH). We find that the DNA methylation status of NMR19-4 is stably inherited and independent of genetic variation. In addition, further analysis indicates that DNA methylation of NMR19-4 correlates with local climates, implying that NMR19-4 is an environmentally associated epiallele. In summary, we discover a novel epiallele, and provide mechanistic insights into its origin and potential function in local climate adaptation.
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