ArticleScientific reports2018
Spinal cholinergic interneurons differentially control motoneuron excitability and alter the locomotor network operational range.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Peptidergic modulation of motor neuron output via CART signaling at C bouton synapses.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- RNA Sequencing and Spatial Transcriptomics in Traumatic Spinal Cord Injury (Review).Sovremennye tekhnologii v meditsine · 2023Review
- Cholinergic Modulation of Locomotor Circuits in Vertebrates.International journal of molecular sciences · 2022Review
- Article
- Locomotion dependent neuron-glia interactions control neurogenesis and regeneration in the adult zebrafish spinal cord.Nature communications · 2021Article
- Ecotoxicity evaluation of polymeric nanoparticles loaded with ascorbic acid for fish nutrition in aquaculture.Journal of nanobiotechnology · 2021Article
- Acetylcholine and spinal locomotor networks: The insider.Physiological reports · 2021Review
- A dynamic role for dopamine receptors in the control of mammalian spinal networks.Scientific reports · 2020Article
- Exploring the mechanisms of graphene oxide behavioral and morphological changes in zebrafish.Environmental science and pollution research international · 2019Article
- Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors.Scientific reports · 2019Article
- Adult spinal motoneurons change their neurotransmitter phenotype to control locomotion.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While cholinergic neuromodulation is important for locomotor circuit operation, the specific neuronal mechanisms that acetylcholine employs to regulate and fine-tune the speed of locomotion are largely unknown. Here, we show that cholinergic interneurons are present in the zebrafish spinal cord and differentially control the excitability of distinct classes of motoneurons (slow, intermediate and fast) in a muscarinic dependent manner. Moreover, we reveal that m2-type muscarinic acetylcholine receptors (mAChRs) are present in fast and intermediate motoneurons, but not in the slow motoneurons, and that their activation decreases neuronal firing. We also reveal a strong correlation between the muscarinic receptor configuration on motoneurons and the ability of the animals to locomote at different speeds, which might serve as a plasticity mechanism to alter the operational range of the locomotor networks. These unexpected findings provide new insights into the functional flexibility of motoneurons and how they execute locomotion at different speeds.
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Registered trials
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