Evidence map›Paper›PMID 29386571›Full record

ArticleScientific reports2018

Pulmonary fibrosis in vivo displays increased p21 expression reduced by 5-HT

Anna Löfdahl, Kristina Rydell-Törmänen, Anna-Karin Larsson-Callerfelt, Christina Wenglén, Gunilla Westergren-Thorsson

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Therapeutic molecular targets of SSc-ILD.Journal of scleroderma and related disorders · 2020
    Article
  8. Article
  9. A Novel Fibroblast Reporter Cell Line forFrontiers in physiology · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anna LöfdahlLung Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden. anna.lofdahl@med.lu.se.
Kristina Rydell-TörmänenLung Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Anna-Karin Larsson-CallerfeltLung Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-7586-3896
Christina WenglénAnaMar AB, Lund, Sweden.
Gunilla Westergren-ThorssonLung Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serotonin (5-hydroxytryptamine) has repeatedly been associated with the development of fibrotic disorders such as pulmonary fibrosis. By blocking the binding of 5-HT to 5-HT

Indexed as

AnimalsBleomycinCell CycleCell ProliferationCyclin-Dependent Kinase Inhibitor p21FemaleFibroblastsGene Expression ProfilingHumansLungMice, Inbred C57BLPulmonary FibrosisReceptor, Serotonin, 5-HT2BSerotonin 5-HT2 Receptor AntagonistsUp-RegulationBleomycinCyclin-Dependent Kinase Inhibitor p21Receptor, Serotonin, 5-HT2BSerotonin 5-HT2 Receptor Antagonists

Identifiers

PMID29386571
PMCPMC5792547
OpenAlexW2789218478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.