ArticleScientific reports2018
In vivo photoacoustic monitoring using 700-nm region Raman source for targeting Prussian blue nanoparticles in mouse tumor model.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Optimization of light source parameters for photoacoustic imaging: trade-offs, technologies, and clinical considerations.JPhys photonics · 2026Review
- High spectral energy density all-fiber nanosecond pulsed 1.7 μm light source for photoacoustic microscopy.Photoacoustics · 2025Article
- Review on Multispectral Photoacoustic Imaging Using Stimulated Raman Scattering Light Sources.Sensors (Basel, Switzerland) · 2025Review
- Correction of high-rate motion for photoacoustic microscopy by orthogonal cross-correlation.Scientific reports · 2024Article
- Efficient label-freePhotoacoustics · 2023Article
- Optical Light Sources and Wavelengths within the Visible and Near-Infrared Range Using Photoacoustic Effects for Biomedical Applications.Biosensors · 2022Review
- High-speed photoacoustic microscopy: A review dedicated on light sources.Photoacoustics · 2021Article
- Ultra-widefield photoacoustic microscopy with a dual-channel slider-crank laser-scanning apparatus forPhotoacoustics · 2021Article
- Quickly Alternating Green and Red Laser Source for Real-time Multispectral Photoacoustic Microscopy.Photoacoustics · 2020Article
- Nanotechnology: a promising method for oral cancer detection and diagnosis.Journal of nanobiotechnology · 2018Review
- Photoacoustic Imaging-Guided Photothermal Therapy with Tumor-Targeting HA-FeOOH@PPy Nanorods.Scientific reports · 2018Article
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Authors and funding
9 authors.
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Abstract
Photoacoustic imaging (PAI) is a noninvasive imaging tool to visualize optical absorbing contrast agents. Due to high ultrasonic resolution and superior optical sensitivity, PAI can be used to monitor nanoparticle-mediated cancer therapy. The current study synthesized Food and Drug Administration-approved Prussian blue (PB) in the form of nanoparticles (NPs) with the peak absorption at 712 nm for photoacoustically imaging tumor-bearing mouse models. To monitor PB NPs from the background tissue in vivo, we also developed a new 700-nm-region stimulated Raman scattering (SRS) source (pulse energy up to 200 nJ and repetition rate up to 50 kHz) and implemented optical-resolution photoacoustic microscopy (OR-PAM). The SRS-assisted OR-PAM system was able to monitor PB NPs in the tumor model with micrometer resolution. Due to strong light absorption at 712 nm, the developed SRS light yielded a two-fold higher contrast from PB NPs, in comparison with a 532-nm pumping source. The proposed laser source involved cost-effective and simple system implementation along with high compatibility with the fiber-based OR-PAM system. The study highlights the OR-PAM system in conjunction with the tunable-color SRS light source as a feasible tool to assist NP-mediated cancer therapy.
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