Evidence map›Paper›PMID 29386424›Full record

ArticleThe Journal of veterinary medical science2018

Phosphodiesterase 9 (PDE9) regulates bovine tracheal smooth muscle relaxation.

Tsuyoshi Tajima, Tamami Shinoda, Norimoto Urakawa, Kazumasa Shimizu, Takeharu Kaneda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. The future of bronchodilation: looking for new classes of bronchodilators.European respiratory review : an official journal of the European Respiratory Society · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tsuyoshi TajimaLaboratory of Veterinary Pharmacology, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-cho, Musashino-shi, Tokyo 180-8602, Japan.
Tamami ShinodaLaboratory of Veterinary Pharmacology, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-cho, Musashino-shi, Tokyo 180-8602, Japan.
Norimoto UrakawaLaboratory of Veterinary Pharmacology, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-cho, Musashino-shi, Tokyo 180-8602, Japan.
Kazumasa ShimizuLaboratory of Veterinary Pharmacology, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-cho, Musashino-shi, Tokyo 180-8602, Japan.
Takeharu KanedaLaboratory of Veterinary Pharmacology, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-cho, Musashino-shi, Tokyo 180-8602, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study was designed to clarify phosphodiesterase 9 (PDE9) expression in bovine tracheal smooth muscle tissue, and to elucidate that PDE9 may contribute to the regulation of airway relaxation. PDE9 mRNA expression was detected in bovine tracheal smooth muscle. Sodium nitroprusside (an NO donor) and BAY 73-6691 (a selective PDE9 inhibitor) reduced high K

Indexed as

AnimalsCattleDose-Response Relationship, DrugMuscle RelaxationMuscle, SmoothPhosphodiesterase InhibitorsPhosphoric Diester HydrolasesPyrazolesPyrimidinesTracheaVardenafil DihydrochlorideBAY 73-6691Phosphodiesterase InhibitorsPhosphoric Diester HydrolasesPyrazolesPyrimidinesVardenafil DihydrochlorideBAY 73-6691PDE9relaxationtracheal smooth muscle

Identifiers

PMID29386424
PMCPMC5880833

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.