ArticleProceedings. Biological sciences2018
Understanding heterogeneities in mosquito-bite exposure and infection distributions for the elimination of lymphatic filariasis.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Lymphatic filariasis in Asia: a systematic review and meta-analysis.Parasitology research · 2021Pooled it
- Molecular surveillance of multiplicity of infection, haplotype frequencies, and prevalence in infectious diseases.PLoS computational biology · 2026Article
- Lymphatic filariasis transmission 10 years after stopping mass drug administration in the Gomoa west district of Ghana.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025Article
- The effects of variable spatial aggregation on lymphatic filariasis transmission.Parasites & vectors · 2025Article
- How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation-A simulated study.PLoS neglected tropical diseases · 2023Article
- Spatial predictive risk mapping of lymphatic filariasis residual hotspots in American Samoa using demographic and environmental factors.PLoS neglected tropical diseases · 2023Article
- Lymphatic filariasis endgame strategies: Using GEOFIL to model mass drug administration and targeted surveillance and treatment strategies in American Samoa.PLoS neglected tropical diseases · 2023Article
- Short-term and long-term epidemiological impacts of sustained vector control in various dengue endemic settings: A modelling study.PLoS computational biology · 2022Article
- Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana.PLoS neglected tropical diseases · 2022Article
- Advances in Understanding Vector Behavioural Traits after Infection.Pathogens (Basel, Switzerland) · 2021Review
- Modelling the Impact of Vector Control on Lymphatic Filariasis Programs: Current Approaches and Limitations.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Review
- Predicting lymphatic filariasis elimination in data-limited settings: A reconstructive computational framework for combining data generation and model discovery.PLoS computational biology · 2020Article
- The Health and Economic Burdens of Lymphatic Filariasis Prior to Mass Drug Administration Programs.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- The basic reproductive number for disease systems with multiple coupled heterogeneities.Mathematical biosciences · 2020Article
- The consequences of Brugia malayi infection on the flight and energy resources of Aedes aegypti mosquitoes.Scientific reports · 2019Article
- Modelling exposure heterogeneity and density dependence in onchocerciasis using a novel individual-based transmission model, EPIONCHO-IBM: Implications for elimination and data needs.PLoS neglected tropical diseases · 2019Article
- Evaluating the Evidence for Lymphatic Filariasis Elimination.Trends in parasitology · 2019Review
- The roadmap towards elimination of lymphatic filariasis by 2030: insights from quantitative and mathematical modelling.Gates open research · 2019Article
- Kernel-density estimation and approximate Bayesian computation for flexible epidemiological model fitting in Python.Epidemics · 2018Article
- Comprehensive Assessment of a Hotspot with Persistent Bancroftian Filariasis in Coastal Sri Lanka.The American journal of tropical medicine and hygiene · 2018Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well known that individuals in the same community can be exposed to a highly variable number of mosquito bites. This heterogeneity in bite exposure has consequences for the control of vector-borne diseases because a few people may be contributing significantly to transmission. However, very few studies measure sources of heterogeneity in a way which is relevant to decision-making. We investigate the relationship between two classic measures of heterogeneity, spatial and individual, within the context of lymphatic filariasis, a parasitic mosquito-borne disease. Using infection and mosquito-bite data for five villages in Papua New Guinea, we measure biting characteristics to model what impact bed-nets have had on control of the disease. We combine this analysis with geospatial modelling to understand the spatial relationship between disease indicators and nightly mosquito bites. We found a weak association between biting and infection heterogeneity within villages. The introduction of bed-nets increased biting heterogeneity, but the reduction in mean biting more than compensated for this, by reducing prevalence closer to elimination thresholds. Nightly biting was explained by a spatial heterogeneity model, while parasite load was better explained by an individual heterogeneity model. Spatial and individual heterogeneity are qualitatively different with profoundly different policy implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.