Evidence map›Paper›PMID 29386325›Full record

Observational studyHeart (British Cardiac Society)2018

Socioeconomic deprivation and mode-specific outcomes in patients with chronic heart failure.

Klaus K Witte, Peysh A Patel, Andrew M N Walker, Clyde B Schechter, Michael Drozd, Anshuman Sengupta, Rowenna Byrom, Lorraine C Kearney, Robert J Sapsford, Mark T Kearney and 1 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Heart (British Cardiac Society), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Article
  8. Impact of Social Determinants of Health on Cardiovascular Disease.Journal of the American Heart Association · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Guideline-directed medical therapy is similarly effective in heart failure with mildly reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2023
    Observational
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Klaus K WitteMultidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, UK.
Peysh A PatelMultidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, UK.
Andrew M N WalkerMultidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, UK.
Clyde B SchechterDepartment of Family and Social Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Michael DrozdMultidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, UK.
Anshuman SenguptaMultidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, UK.
Rowenna ByromMultidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, UK.
Lorraine C KearneyMultidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, UK.
Robert J SapsfordDepartment of Cardiology, Leeds General Infirmary, Leeds, UK.
Mark T KearneyMultidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, UK.
Richard M CubbonMultidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, UK.ORCID 0000-0001-7844-3600

Funding

British Heart Foundation CH/13/1/30086British Heart Foundation FS/11/94/29180British Heart Foundation FS/12/80/29821British Heart Foundation FS/14/10/30472British Heart Foundation FS/15/9/31092British Heart Foundation PG/08/020/24617British Heart Foundation PG/11/89/29085Department of Health NIHR-CS-012-032
6 · The paper itself

Abstract

objectiveTo characterise the association between socioeconomic deprivation and adverse outcomes in patients with chronic heart failure (CHF).

methodsWe prospectively observed 1802 patients with CHF and left ventricular ejection fraction (LVEF) ≤45%, recruited in four UK hospitals between 2006 and 2014. We assessed the association between deprivation defined by the UK Index of Multiple Deprivation (IMD) and: mode-specific mortality (mean follow-up 4 years); mode-specific hospitalisation; and the cumulative duration of hospitalisation (after 1 year).

resultsA 45-point difference in mean IMD score was noted between patients residing in the least and most deprived quintiles of geographical regions. Deprivation was associated with age, sex and comorbidity, but not CHF symptoms, LVEF or prescribed drug therapy. IMD score was associated with the risk of age-sex adjusted all-cause mortality (6% higher risk per 10-unit increase in IMD score; 95% CI 2% to 10%; P=0.004), and non-cardiovascular mortality (9% higher risk per 10-unit increase in IMD score; 95% CI 3% to 16%; P=0.003), but not cardiovascular mortality. All-cause, but not heart failure-specific, hospitalisation was also more common in the most deprived patients. Overall, patients spent a cumulative 3.3 days in hospital during 1 year of follow-up, with IMD score being associated with the age-sex adjusted cumulative duration of hospitalisations (4% increase in duration per 10-unit increase in IMD score; 95% CI 3% to 6%; P<0.0005).

conclusionsSocioeconomic deprivation in people with CHF is linked to increased risk of death and hospitalisation due to an excess of non-cardiovascular events.

Indexed as

Social Determinants of HealthSocioeconomic FactorsAgedChronic DiseaseFemaleHeart FailureHospitalizationHumansMalePovertyPrognosisProspective StudiesRisk FactorsStroke VolumeTime FactorsUnited Kingdomdeprivationheart failurehospitalisationmortalitysocioeconomic

Identifiers

PMID29386325
PMCPMC5992368

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.