Evidence map›Paper›PMID 29386297›Full record

ArticleMolecular biology of the cell2018

Dynein pulling forces counteract lamin-mediated nuclear stability during nuclear envelope repair.

Lauren Penfield, Brian Wysolmerski, Michael Mauro, Reza Farhadifar, Michael A Martinez, Ronald Biggs, Hai-Yin Wu, Curtis Broberg, Daniel Needleman, Shirin Bahmanyar

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 55 citations in OpenAlex.

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  12. Mechanics and functional consequences of nuclear deformations.Nature reviews. Molecular cell biology · 2022
    Review
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  19. Genome instability from nuclear catastrophe and DNA damage.Seminars in cell & developmental biology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lauren PenfieldDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520.
Brian WysolmerskiDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520.
Michael MauroDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520.
Reza FarhadifarDepartment of Molecular and Cellular Biology, School of Engineering and Applied Sciences, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138.
Michael A MartinezDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520.
Ronald BiggsDepartment of Cellular & Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093.
Hai-Yin WuDepartment of Molecular and Cellular Biology, School of Engineering and Applied Sciences, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138.
Curtis BrobergDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520.
Daniel NeedlemanDepartment of Molecular and Cellular Biology, School of Engineering and Applied Sciences, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138.
Shirin BahmanyarDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520.
Yale University · USHarvard University · USUniversity of California San Diego · US

Funding

Skill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007499 · NIGMS · YALE UNIVERSITY · PI CARLSON, JOHN R, REINKE, VALERIE J · 1985 to 2022
$13.9M
Forces in Asymmetric Spindle Positioning in Mouse OocytesR21HD080057 · NICHD · HARVARD UNIVERSITY · PI NEEDLEMAN, DANIEL · 2015 to 2016
$463k
NICHD NIH HHS R21 HD080057NIGMS NIH HHS T32 GM007223NIGMS NIH HHS T32 GM007499
6 · The paper itself

Abstract

Recent work done exclusively in tissue culture cells revealed that the nuclear envelope (NE) ruptures and repairs in interphase. The duration of NE ruptures depends on lamins; however, the underlying mechanisms and relevance to in vivo events are not known. Here, we use the

Identifiers

PMID29386297
PMCPMC5905298
OpenAlexW2786777567

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.