ArticleJournal of virology2018
Conserved Surface Residues on the Feline Calicivirus Capsid Are Essential for Interaction with Its Receptor Feline Junctional Adhesion Molecule A (fJAM-A).
Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Feline calicivirus localization in central nervous system cells of cats with neurological lesions.Veterinary and animal science · 2026Article
- Localized adaptive evolution in VP1 drives antigenic divergence of feline calicivirus despite high sequence conservation.Veterinary research · 2026Article
- Evaluating Neutralizing Antibody Titers by Recombinant Feline Calicivirus with Heterologous Capsid Protein VP1.Animals : an open access journal from MDPI · 2026Article
- Genetic Diversity and Biological Characteristics of a Novel Feline Calicivirus Strain Isolated From Zoo-Captive South China Tiger (Panthera tigris amoyensis).Transboundary and emerging diseases · 2026Article
- Beyond TFRC: The Pivotal Role of mGluR2 in Feline Calicivirus Entry and Replication.Veterinary sciences · 2025Article
- Feline Calicivirus Infection: Current Understanding and Implications for Control Strategies.Animals : an open access journal from MDPI · 2025Review
- Unlocking the secrets of Feline calicivirus: advances in structural and nonstructural proteins and its role as a key model for other Caliciviruses.Virology journal · 2025Review
- Isolation, Identification, and Genetic Evolution Analysis ofInternational journal of molecular sciences · 2025Article
- Epidemiology and Molecular Characterization of Feline Calicivirus in Beijing, China.Animals : an open access journal from MDPI · 2025Article
- Exploring non-alcohol-based disinfectant: virucidal efficacy of arginine and Zinc chloride against feline calicivirus.Frontiers in microbiology · 2025Article
- Analysis of Genetic Diversity Based on Sequences of Feline Calicivirus Strains Isolated in China.Transboundary and emerging diseases · 2025Article
- Conformational Flexibility in Capsids Encoded by theViruses · 2024Review
- VP2 mediates the release of the feline calicivirus RNA genome by puncturing the endosome membrane of infected cells.Journal of virology · 2024Article
- Genetic Evolution and Biological Characteristics of Feline Caliciviruses Isolated from Dogs.Transboundary and emerging diseases · 2023Article
- Calicivirus Infection in Cats.Viruses · 2022Review
- Precise location of linear epitopes on the capsid surface of feline calicivirus recognized by neutralizing and non-neutralizing monoclonal antibodies.Veterinary research · 2020Article
- The Carboxyl Terminus of the Porcine Circovirus Type 2 Capsid Protein Is Critical to Virus-Like Particle Assembly, Cell Entry, and Propagation.Journal of virology · 2020Article
- Article
- High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Host cell surface receptors are required for attachment, binding, entry, and infection by nonenveloped viruses. Receptor binding can induce conformational changes in the viral capsid and/or the receptor that couple binding with downstream events in the virus life cycle (intracellular signaling, endocytosis and trafficking, and membrane penetration). Virus-receptor interactions also influence viral spread and pathogenicity. The interaction between feline calicivirus (FCV) and its receptor, feline junctional adhesion molecule A (fJAM-A), on host cells is required for infection and induces irreversible, inactivating conformational changes in the capsid of some viral strains. Cryoelectron microscopy (cryo-EM) structures of FCV bound to fJAM-A showed several possible virus-receptor interactions. However, the specific residues on the viral capsid required for binding are not known. Capsid residues that may be involved in postbinding events have been implicated by isolation of soluble receptor-resistant (srr) mutants in which changes in the capsid protein sequence change the capacity of such srr mutants to be inactivated upon incubation with soluble fJAM-A. To clarify which residues on the surface of FCV are required for its interaction with fJAM-A and to potentially identify residues required for postreceptor binding events, we used the existing atomic-resolution structures of FCV and the FCV-fJAM-A cryo-EM structures to select 14 capsid residues for mutation and preparation of recombinant viral capsids. Using this approach, we identified residues on the FCV capsid that are required for fJAM-A binding and other residues that are not required for binding but are required for infection that are likely important for subsequent postbinding events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.