Evidence map›Paper›PMID 29386263›Full record

ArticleJournal of clinical microbiology2018

Simultaneous Immunodetection of Anthrax, Plague, and Tularemia from Blood Cultures by Use of Multiplexed Suspension Arrays.

Adva Mechaly, Einat Vitner, Haim Levy, Shay Weiss, Elad Bar-David, David Gur, Michal Koren, Hila Cohen, Ofer Cohen, Emanuelle Mamroud and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Study on the detection of anthrax by ICP-MS based on gold nanoparticle labeling.Technology and health care : official journal of the European Society for Engineering and Medicine · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Biodefence research two decades on: worth the investment?The Lancet. Infectious diseases · 2021
    Review
  7. Review
  8. Article
  9. TheMicroorganisms · 2020
    Review
  10. Rapid and Sensitive Multiplex Assay for the Detection ofPathogens (Basel, Switzerland) · 2020
    Article
  11. Detection and Identification ofMicroorganisms · 2020
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Adva MechalyDepartment of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel.
Einat VitnerDepartment of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel.
Haim LevyDepartment of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel.
Shay WeissDepartment of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel.
Elad Bar-DavidDepartment of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel.
David GurDepartment of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.
Michal KorenDepartment of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel.
Hila CohenDepartment of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.
Ofer CohenDepartment of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.
Emanuelle MamroudDepartment of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.
Morly FisherDepartment of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel morlyf@iibr.gov.il.
Israel Institute for Biological Research · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiplexed detection technologies are becoming increasingly important given the possibility of bioterrorism attacks, for which the range of suspected pathogens can vary considerably. In this work, we describe the use of Luminex MagPlex magnetic microspheres for the construction of two multiplexed diagnostic suspension arrays, enabling antibody-based detection of bacterial pathogens and their related disease biomarkers directly from blood cultures. The first 4-plex diagnostic array enabled the detection of both anthrax and plague infections using soluble disease biomarkers, including protective antigen (PA) and anthrax capsular antigen for anthrax detection and the capsular F1 and LcrV antigens for plague detection. The limits of detection (LODs) ranged between 0.5 and 5 ng/ml for the different antigens. The second 2-plex diagnostic array facilitated the detection of

Indexed as

AnthraxAntibodies, BacterialAntigens, BacterialBacillus anthracisBiomarkersBioterrorismBlood CultureFrancisella tularensisHumansMagnetsMicrospheresPlaguePolymerase Chain ReactionProtein Array AnalysisSensitivity and SpecificityTularemiaAntibodies, BacterialAntigens, BacterialBiomarkersanthraxblood cultureimmunodetectionmagnetic beadsmultiplexplaguetularemia

Identifiers

PMID29386263
PMCPMC5869844
OpenAlexW2789894702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.