ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Neurons in Primate Entorhinal Cortex Represent Gaze Position in Multiple Spatial Reference Frames.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 82 citations in OpenAlex.
- Neural geometry in the human hippocampus enables generalization across spatial position and gaze.ArXiv · 2026Article
- Distinctive roles of left and right entorhinal cortex in path integration via a non-invasive stimulation study.Nature communications · 2025Article
- Distinct brain regions map olfactory and visual spaces.bioRxiv : the preprint server for biology · 2025Article
- Article
- Visual Exploration and the Primate Hippocampal Formation.Hippocampus · 2025Review
- Electrode Arrays for Detecting and Modulating Deep Brain Neural Information in Primates: A Review.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- The medial entorhinal cortex encodes multisensory spatial information.Cell reports · 2024Article
- Electrophysiological signatures of veridical head direction in humans.Nature human behaviour · 2024Article
- Grid cells: the missing link in understanding Parkinson's disease?Frontiers in neuroscience · 2024Article
- Sequential involvements of the perirhinal cortex and hippocampus in the recall of item-location associative memory in macaques.PLoS biology · 2023Article
- Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans.Hippocampus · 2023Review
- Gated transformations from egocentric to allocentric reference frames involving retrosplenial cortex, entorhinal cortex, and hippocampus.Hippocampus · 2023Review
- Computational cross-species views of the hippocampal formation.Hippocampus · 2023Review
- Selective neural coding of object, feature, and geometry spatial cues in humans.Human brain mapping · 2022Article
- Linking global top-down views to first-person views in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Eye movements reveal spatiotemporal dynamics of visually-informed planning in navigation.eLife · 2022Article
- Multiple spatial frames for immersive working memory.Nature human behaviour · 2022Article
- Article
- The grid code for ordered experience.Nature reviews. Neuroscience · 2021Review
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2 authors at 1 institution in 1 country.
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Abstract
Primates rely predominantly on vision to gather information from the environment and neurons representing visual space and gaze position are found in many brain areas. Within the medial temporal lobe, a brain region critical for memory, neurons in the entorhinal cortex of macaque monkeys exhibit spatial selectivity for gaze position. Specifically, the firing rate of single neurons reflects fixation location within a visual image (Killian et al., 2012). In the rodents, entorhinal cells such as grid cells, border cells, and head direction cells show spatial representations aligned to visual environmental features instead of the body (Hafting et al., 2005; Sargolini et al., 2006; Solstad et al., 2008; Diehl et al., 2017). However, it is not known whether similar allocentric representations exist in primate entorhinal cortex. Here, we recorded neural activity in the entorhinal cortex in two male rhesus monkeys during a naturalistic, free-viewing task. Our data reveal that a majority of entorhinal neurons represent gaze position and that simultaneously recorded neurons represent gaze position relative to distinct spatial reference frames, with some neurons aligned to the visual image and others aligned to the monkey's head position. Our results also show that entorhinal neural activity can be used to predict gaze position with a high degree of accuracy. These findings demonstrate that visuospatial representation is a fundamental property of entorhinal neurons in primates and suggest that entorhinal cortex may support relational memory and motor planning by coding attentional locus in distinct, behaviorally relevant frames of reference.
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